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Ribavirin 4
Ribavirin 4
Ribavirin 4
Presented by :
• Shahd Diefalla 236025 Mohrael Yasser 232681
• Reham Gomaa 237899 Moamen Gaser 232557
• Radwa Mahmoud 236713 Ahmed Ahmed 238311
Presented to :
Dr.Amal
Introduction
• Chemical Formula:
N
N
C14H24N4O5
N
H O
O H
H O
• IUPAC nomenclature
[(2R,3R,4S,5R)-3,4-dihydroxy-5-
(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-
carboxamide
• Types of bonds
𝞂 Double bond (𝞂-π )
H N
2 O
𝞂 Double bond (𝞂-π )
𝞂
N
N
Double bond (𝞂-π ) 𝞂
N
𝞂 𝞂
𝞂 O
𝞂
𝞂 H O
𝞂
O H
𝞂 𝞂 H O
𝞂
𝞂 𝞂
C-C non polar covalent bond
N-N non polar covalent bond 𝞂:sigma bond
C-N polar covalent bond π:pi bond
C-O polar covalent bond
• Types of hybridization
sp2
H N
2
sp2 O
N sp2
N
sp3 O
sp3
H O
O H
H O
sp3
sp3 sp3
• Mesomeric and
inductive effect
H N -M
+M 2
O
N
N -I
N
HO
OH
HO
• Reference
1. Thomas E, Ghany MG, Liang TJ. The application and
mechanism of action of ribavirin in therapy of hepatitis C.
Antiviral Chemistry and Chemotherapy. 2012 Aug;23(1):1-2.