Professional Documents
Culture Documents
Tablet Excipients
Tablet Excipients
- Disintegrate may also be added in two - Disintegrate can be - It is more common for the
steps: mixed with other disintegrate to be mixed
A portion is added to the drug-diluent ingredients prior to with the dry granules before
mixture (Intragranular addition) and granulation . tablet compression
the other portion is mixed with the dry
granules before compression (Extra
granular addition)
Examples for disintegrates
Common disintegrates include:
- Talc.
- Waxes.
Problems due to lubricants
1- They may reduce tablet strength (HOW?) due
to their interference with the bonding
between the particles during compression.