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Managament of Migraine
Managament of Migraine
Migraine Facts
Migraine is one of the common causes of recurrent headaches According to IHS, migraine constitutes 16% of primary headaches Migraine afflicts 10-20% of the general population More than 2/3 of migraine sufferers either have never consulted a doctor or have stopped doing so Migraine is underdiagnosed and undertreated Migraine greatly affects quality of life. The WHO ranks migraine among the worlds most disabling medical illnesses
Burden Of Migraine
World - 15-20% of women and 10-15% of men suffer from migraine In India, 15-20% of people suffer from migraine Adults Female: Male ratio is 2 : 1 In childhood migraine, boys and girls are affected equally until puberty, when the predominance shifts to girls.
NEJM 2002; 346(4): 257-269; XI Congress of the IHS, 2004
Migraine - Definition
Migraine is a familial disorder characterized by recurrent attacks of headache widely variable in intensity, frequency and duration. Attacks are commonly unilateral and are usually associated with anorexia, nausea and vomiting -World Federation of Neurology
Migraine Triggers
Food Disturbed sleep pattern Hormonal changes Drugs Physical exertion Visual stimuli Auditory stimuli Olfactory stimuli Weather changes Hunger Psychological factors
PRODROME
Vague premonitory symptoms that begin from 12 to 36 hours before the aura and headache Symptoms include Yawning Excitation Depression Lethargy Craving or distaste for various foods Duration 15 to 20 min
AURA
Aura is a warning or signal before onset of headache Symptoms
HEADACHE
Headache is generally unilateral and is associated with symptoms like: Anorexia Nausea Vomiting Photophobia Phonophobia Tinnitus Duration is 4-72 hrs
POSTDROME (RESOLUTION
PHASE)
Following headache, patient complains of
MIGRAINE CLASSIFICATION
According to Headache Classification Committee of the International Headache Society, Migraine has been classified as:
Migraine without aura (common migraine) Migraine with aura (classic migraine) Complicated migraine
Unilateral throbbing headache Unilateral throbbing headache may be accompanied by nausea and later becomes generalised and vomiting During headache, patient complains of phonophobia and photophobia Patient complains of visual disturbances and may have mood variations
MIGRAINE - PATHOPHYSIOLOGY
VASCULAR THEORY
Intracerebral
PRESENT UNDERSTANDING Neurovascular process, in which neural events result in activation of blood vessels, which in turn results in pain and further nerve activation
NEUROVASCULAR PROCESS
Arterial Activation
Release of Neurotransmitter
Worsening of Pain
MIGRAINE: DIAGNOSIS
Medical History Headache diary Migraine triggers Investigations (only to exclude secondary causes) EEG CT Brain MRI
Strictly unilateral Tension headaches: Do not have the associated features like nausea, vomiting, photophobia, phonophobia. The muscle contraction leads to headache. Headache quality is of a tightening (non-pulsating) quality. Usually bilateral. Intensity is mild or moderate Cluster headaches: Severe unilateral pain. Headache associated with lacrimation, nasal congestion, rhinorrhea, facial sweating or eyelid edema. Pain lasts for 15 to 180 minutes. More common in men
Reducing the attack frequency and severity Avoiding escalation of headache medication Educating and enabling the patient to manage the disorder Improving the patients quality of life
MIGRAINE MANAGEMENT
Non-pharmacological treatment Identification of triggers Meditation Relaxation training Psychotherapy Pharmacotherapy non-specific Abortive therapy specific Preventive therapy
Dose
500-650 mg 500 mg-4 g 200- 300 mg 50-100 mg 500-750 mg
Route
Oral Oral Oral Oral/IM Oral
Dose
Route
Dose (mg)/d
10-80 mg 5-10 mg 50-125 mg 10-25 mg
Route
Oral Oral/IV Oral/IM Oral/IV
Abortive drugs should not be used more than 2-3 times a week Long-term prophylaxis improves quality of life by reducing frequency and severity of attacks 80% of migraineurs may require prophylaxis
Betablockers Propranolol Calcium Channel Blockers Flunarizine Verapamil TCAs Amitriptyline SSRIs Fluoxetine
2.
3.
10-20 20-60
4.
Dose (mg/d)
600-1200 4-8
Anti-convulsant
6.
Anti-histaminic
Gold standard in migraine prophylaxis Established efficacy and safety in migraine prophylaxis
PROPRANOLOL MECHANISMS OF
ACTION Mechanisms proposed
Short t of 3-5 hrs Multiple daily dosing required to maintain adequate degree of beta-receptor blockade throughout 24 hr Poor patient compliance may compromise efficacy
Migraine patients are asymptomatic between attacks Important to minimize number of daily doses during prophylactic treatment Once-daily administration improves compliance Stable drug concentration for 24 hrs
PROPRANOLOL REDUCES THE FREQUENCY OF ATTACKS PER MONTH IN BOTH COMMON AS WELL AS CLASSIC MIGRAINE PATIENTS
n = 51 Duration = 12 weeks
Variable
Propranolol-LA 160
Propranolol-LA 80 3.9* n = 18
6.1
3.4* n = 27
Propranolol-LA 80 mg appears to have adequate prophylactic effect for migraine and may be better tolerated than propranolol-LA 160 mg, which appears to offer no additional benefits.
*p < 0.001
Cephalalgia 1990; 10: 101-105
Baseline
11.1
End-period
6.7*
n = 48
% of Patients
Severity score
6.3
4.5
4.1
*
3.4 Baseline 16 weeks
Propranolol
Headache 1989; 29: 218-223
DOSAGE OF PROPRANOLOL
Starting dose: 40-80 mg once daily Max. dose/day: 240 mg If satisfactory response is not obtained within 4-6 weeks, after reaching the maximal dose, therapy should be discontinued Taper slowly to avoid rebound headache and adrenergic side effects Max. duration: 9 to 12 months
The dose of the long-acting formulation may need to be higher than the total daily dose of the conventional formulation