Roehampton

university

Alzheimer’s
disease
Research project
Date June 20, 20XX
Rihab Laaouaj
LAA22518822
Content:
 Introduction/ Thesis statement.

 Impact of Alzheimer's disease.

 Alzheimer's treatment.

 Conclusion.

 Reference list.
Introduction
:
 Alzheimer’s disease (AD) is the most
frequent cause of dementia

 More than 850,000

(Alzheimer’s individuals with
Society,2022)
AD in the UK.
(Alzheimer's disease facts and figures 2019)
Thesis statement:

 This presentation will argue that …

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 Impact of AD:
1- Psychological 2 - Physical
effect:
 Depression
effects:
(Perel, 1998)

 Changes in mood  Inhaling food

◦
(Alzheimer's disease facts and
figures, 2009)
 Fluids into their lungs

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Alzheimer's treatment
1-Pharmacological treatments:
Aducanumab :
 An effective treatment with 20%  rate of success.
(Servick, 2022)
 Costs nearly 150 000 US dollar .
(Ross, Weinberg and Arnold, 2022)

Donepezil :
 Its dropout instances made up (5%–13%)
(Cacabelos, 2022)
 Side effects: difficulty controlling urination and weight loss.
(Donepezil - Medicine - NHS, 2022)

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Alzheimer's treatment
2-Non-Pharmacological treatments:
 -Brain training games: minimise mental decline.
(non-drug interventions for Alzheimer’s disease, 2022)

-Reality Orientation: founded on the theoretical principles of mental functioning.

(Camargo, Justus and Retzlaff, 2015)

-Memory aids: improve cognition.

(Zucchella et al., 2018)

 They are effective with early-stage of AD.

(Ballard, Khan, Clack and Corbett, 2011)

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Conclusion:
The best way to lessen symptoms quickly:

Combining Donepezil (pharmacological treatment) with nonpharmacological

treatment.

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References:
Alzheimer's & Dementia, 2019. 2019 Alzheimer's disease facts and figures. [online] 15(3), pp.321-387. Available at:
<https://alzjournals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2019.01.010> [Accessed 17 June 2022].

Alzheimer's Society. 2022. Alzheimer's Society Annual Conference 2022. [online] Available at: <https://www.alzheimers.org.uk/dementia-professionals/conferences-and-events/annual
conference> [Accessed 17 June 2022].

Gehrman, P., Gooneratne, N., Brewster, G., Richards, K. and Karlawish, J., 2018. Impact of Alzheimer disease patients' sleep disturbances on their caregivers. Geriatric Nursing, [online] 39(1),
pp.60-65. Available at: <https://www.sciencedirect.com/science/article/pii/S0197457217301568> [Accessed 17 June 2022].

Alzheimer's &amp; Dementia, 2009. 2009 Alzheimer's disease facts and figures. [online] 5(3), pp.234-270. Available at: <https://alz-journals.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/
j.jalz.2009.03.001> [Accessed 17 June 2022].

Servick, K., 2022. Alzheimer's drug approved despite doubts about effectiveness. [online] Science.org. Available at: <https://www.science.org/content/article/alzheimer-s-drug-approved-despite-
doubts-about-effectiveness> [Accessed 17 June 2022].

Ross, E., Weinberg, M. and Arnold, S., 2022. Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US. JAMA Neurology, 79(5), p.478. Available at:
https://jamanetwork.com/journals/jamaneurology/article-abstract/2790531[Accessed 17 June 2022].

Cacabelos, R., 2022. Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics. [online] PubMed Central (PMC). Available at:
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654795/> [Accessed 17 June 2022].

nhs.uk. (2020). Donepezil - Medicine - NHS. [online] Available at: https://www.nhs.uk/medicines/donepezil/#:~:text=Donepezil%20is%20a%20medicine%20th> [Accessed 17 June 2022].

Ncbi.nlm.nih.gov. 2022. Non-drug interventions for Alzheimer’s disease. [online] Available at: <https://www.ncbi.nlm.nih.gov/books/NBK279355/#:~:text=Non%2Ddrug%20interventions
%20for%20Alzheimer's%20disease%20include%20things%20like%20memory,performance%20and %20increase%20their%20independence.> [Accessed 17 June 2022].

Camargo, C., Justus, F. and Retzlaff, G., 2015. The Effectiveness of Reality Orientation in the Treatment of Alzheimer’s Disease. American Journal of Alzheimer's Disease
&amp; Other Dementiasr, [online] 30(5), pp.527-532. Available at: <https://journals.sagepub.com/doi/full/10.1177/1533317514568004> [Accessed 17 June 2022].

Zucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R. and Bartolo, M., 2018. The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A
Narrative Review of Non-Pharmacological Treatment. Frontiers in Neurology, [online] 9. Available at: <https://www.frontiersin.org/articles/10.3389/fneur.2018.01058/full> [Accessed 17 June
2022].

Ballard, C., Khan, Z., Clack, H. and Corbett, A. (2011). Nonpharmacological Treatment of Alzheimer Disease. The Canadian Journal of Psychiatry, 56(10), pp.589–595.
doi:10.1177/070674371105601004. Available at: https://pubmed.ncbi.nlm.nih.gov/22014691/ [Accessed 17 June 2022].

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 Thank you

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