SYSTEMIC LUPUS

ERYTHEMATOSUS

ARPITHA G P
ROLL NO - 11
WHAT IS SLE?
Itis a chronic ,multisystemic autoimmune
disease that results from immune system
mediated tissue damage and is characterized
by the presence of broad spectrum
autoantibodies.

Itpredominantly affects young women between

20 to 30 years, with female to male ratio of 9:1.
HISTORY
 Lupus is the latin word for “Wolf”.
 Erythomatosus means “Red rashes”. Dr.
Cazenave discovered red rashes on patients face that
looked like wolf bites. He named the rash Discoid
Lupus Erythematosus[DLE].

 Then Sir William Osler recognized that many people

with lupus had a disease involving not only the skin but
many other organs or systems. He named Systemic
Lupus Erythematosus[SLE].
PATHOPHYSIOLOGY
CLINICAL FEATURES
Laboratory Investigations:
Antinuclear antibodies[ANA]
Anti dsDNA antibody
Anti Smith antibody
Antiphospholipid antibody[APA]
Complements C3 and C4
Inflammatory biomarkers [ CRP,ESR]
CBC
Others; [ ECG, Radiology]
DIAGNOSIS:

4/11 Criteria-
Definite SLE
3/11 Criteria-
Probable SLE
2/11 Criteria-
Possible SLE
TREATMENT:
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