Connect the three

Connect X,Y,Z
• Disease X is associated with aphthous ulcers. Some consider the
elevated immunoglobulins detected in X as an epiphenomenon
• Disease Y is a severe version of X which is characterized by severe
febrile episodes, ataxia, mental retardation & even death

• An unrelated more common genetically linked skin condition Z shares

genetics with X and Y. Clues to Z are given in next slide…..
Z.
• The person in picture was resident of Elba (island known for
Napoleonic fame)
• Was influenced by Paul Gerson Unna
• Academic controversy regarding disease Z between man in picture &
Dr Emilio Respighi

What connects X, Y and Z?

Name X, Y & Z also