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Antihypertension
Antihypertension
Antihypertension
Angiotensin II arteriolar vasocontraction, induce ADH secretion(pituitary gland posterior lobe), sympathetic activity. Vaso-
constrictor action on the efferent arterioles of the renal glomerulus: glomerular filtration
Aldosterone NA+, Cl- reabsorption, K+ secretion, H2O retention, Renal sodium reabsorption & blood volume
Drug Target: Renin, ACE, angiotensin II receptor antagonist, aldosterone receptor antagonist, beta blocker (aldos-
terone)
Adverse effects
• Libido Sexual dysfunction & erectile dysfunction
• Hypotension (exaggerated pharmacology)
• Bradycardia (exaggerated pharmacology)
• Fatigue, insomnia
• Alterations in lipid profiles: HDL, TG
• In case of drug withdrawl: aggravation of heart conditions
(hypertension,
angina, myocardial infarction)
3.3 Alpha blockers
Class MOA Example
Hydrogen bonding
cofactor hydrophobic hydrophobic Ionic interaction
Positive charge
Arginine
Histidine
lysine
Calcium channel
DHP(dihydropyridine): vascular smooth muscle.
L-type (long-lasting) voltage-gated calcium
DPA (diphenyl alkylamines, verapamil) : pore blocker
channel
on both cardiac & vascular smooth muscle.( 특히 심장 )
Composed of α, β, γ, δ subunits
Benzothiazepine (diltiazem): cardiac & vascular smooth
Calcium rushing into cells causes contraction of
muscle
vascular (arteriole) smooth muscle and
myocardium.
3.8 Others
ATC code •의약품 분류를 위해 WHO 에 의해 관리되는 공통 체계 .
(anatomical therapeutic •장기 > 계통 > 화학적 특성 > 효능 등에 따라 5 개
chemical classification 하위수준으로 분류
system) •알파벳 / 두 자리 숫자 / 알파벳 / 알파벳 / 두 자리 숫자