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Chapter 7 2010 - Hardy-Weinberg
Chapter 7 2010 - Hardy-Weinberg
http://www.derwenttraders.com.au/contents
/media/silvereye-460.jpg
6.13b
Founder effect in
Silvereyes
Analysis of microsatellite DNA from
populations shows Founder effect on
populations.
http://people.brandeis.edu/~msitzman/docs/pingelap_large.html
Founder effect in human
populations
One survivor was heterozygous carrier
of a recessive loss of function allele of
CNGB3 gene.
That gene codes for protein in cone
cells of retina.
4 generations after typhoon
homozygotes for allele began to be
born.
Founder effect in human
populations
People homozygous for the allele have
achromotopsia (complete color
blindness, extreme light sensitivity,
and poor visual acuity).
Achromotopsia is rare in most
populations (<1 in 20,000 people).
Among the 3,000 Pingelapese
islanders the frequency is 1 in 20.
Founder effect in human
populations
High frequency of allele for
achromotopsia is not due to a
selective advantage, just a result of
chance.
photo: www.turtletrack.org
Inbreeding in California
Sea Otters
Hf =Ho (1-F)
Female Male
Fig 6.27a
Fig 6.27b
General analysis of
inbreeding
Total probability of scenario is 1/16 +
1/16 = 1/8.
Inbreeding depression
Inbreeding increases the frequency of
homozygotes and thus the probability that
deleterious alleles are visible to selection
because an individual will receive two copies
of the deleterious allele.
Population increased.