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Wound Healing
Wound Healing
• Produced by:
– Platelets and macrophages
MOST IMPORTANT FACTOR IN WOUND
HEALING
• Actions:
– Monocyte chemotaxis
– Fibroblast migration and proliferation
– Angiogenesis and fibronectin synthesis
– Collagen and ECM:
• Increased synthesis
• Decreased degradation by MMP’s, increased TIMP’s
VEGF and FGF- produced by macrophages
and increases angiogenesis
• PDGF – produced by platelets, is mitogenic
for fibroblasts and increases collagen
• EGF – produced by macrophages, is
mitogenic for keratinocytes and
macrophages - GRANULATION TISSUE
Wound Healing Cutaneous wound
healing is generally divided into 4 phases:
1.Homeostasis.
2.Inflammation.
3.Granulation tissue formation and Re-
epithelialization
4.Remodeling. - Wound healing is a
CAPILLARY
FIBROBLAST
GRANULATION TISSUE
4. Remodeling
- After the third week, the wound undergoes
constant alterations, known as remodeling.
Collagen is deposited from fibroblasts and
degraded by collagenase enzyme which secreted
from macrophages in a controlled manner.
Wound contraction is a process occurs by the
strength.
Possible outcomes after injury
Regeneration