Pharmaceutical Technology

Summary of practical performances

“Formulation and characterization of domperidone transdermal patches.”

Presented By:
Mi Pharma Industries Pvt. Ltd.
Members:
Mahnoor Younas……….. 2017-pharmd-033
Hajra Muzaffar…………. 2017-pharmd-040
Muqarab Abbas ………... 2017-pharmd-042
M. Asif Jamshaid ………. 2017-pharmd-043
Muhammad Yousaf ……... 2017-pharmd-048
Transdermal Drug Delivery System
 Melting Point:

Sample on Stage Observation

M.P Equipment

Crystallinity:

Spherical shape
Sample on slide Microscopic examination

Buffer: (7.4)

Take the ingred. Weigh/ measure ingred. Mix them well separately Make up final Vol. Check pH (7.4)
Muqarrab Abbas(42-M)
Oral 17-
19%

Urine&
feaces PK Hepatic

Half
life
7.5hr

Buffer 6.8:

Potassium monobasic Sodium Hydroixe-89.6 mg Weighing Buffer

phosphate-680mg
Solubility Analysis:
Gravimetric method

Buffer 6.8 Sample addition Dissolution Filtration Evaporation Weigh & calculation
Making of Dilutions
• 2mg/ml stock
Sol. Absorbance of domperidone
Stock soln. • 2000µg/ml 2
at 285.9 nm
1.5

Absorbance
• 2.5 ml stock in
Working 47.7ml Buffer 1
soln • 5000µg/50ml
0.5
• 5 0.5ml in 9.5ml of buffer
• 10 1ml 0
0 5 10 15 20 25 30
• 15 1.5ml
Dilutions • 20 2ml conc (µg/ml)
• 25 3ml
HAJRA MUZAFFAR(40M)

Side effects of Domperidone. Determination of calibration curve

1. Cardiac problems 1. 2.5ml stock solution+ 50ml working
2. Erectile dysfunctioning solution
3. Absence of menstrual period 2. 5 dilutions made with multiple of 5
4. Glactogogue damages infant’s 3. Check absorbance in
health. spectrophotometer and made graph.

Transdermal drug delivery Buffer 1.2

system 0.2M, 8.5ml hcl+5ml kcl+2oml volume
makeup in volumetric flask
 M. Yousaf (48)

Transdermal drug delivery system-----

Permeation enhancers:
• Ideal Properties.
• Mechanism.
• Examples.

Domperidone…Stability Studies:
Shelf-Life.
Optimal Storage Conditions.

Pre-Formulation Studies… Flow Properties :

I. Angle Of Repose:31.29.
II. Hausner Ratio:1.15.
III. Carr’s Index:14.19.
Buffer “8”:

Calculation Weighing Mixing Volume Checking pH

Making
(Domperidone was insoluble in this buffer).
Calibration Curve:

Making of Dilutions Checking Absorbance Drawing Calibration Curve

MAHNOOR YOUNAS(033
 Average particle size of DMP was
Found 21-45micrometer..

5.8 pH buffer
THANK YOU