INTRODUCTION

• Chronic renal failure is gradual ,progressive and

irreversible deterioration of kidney tissue.
• Results from
 chronic intrinsic renal disease,
 progressive bilateral nephropathy ,
 non renal disease like obstructive renal nephropathies
• Marked loss of flexibility of renal homeostatic
function.
 CAUSES OF CHRONIC RENAL FAILURE

• Ischeamia
• Increase intrapelvic pressure
• Infection with microorganism
• Deposition of complement binding antigen-antibody
complexes
• Diffuse ,bilateral pregressive form of
glomerulonephritis
 CONDITIONS COMMONLY LEADING TO
CHRONIC RENAL FAILURE

• Glomerulonephritis
• Pyelonephritis
• Polycystic disease of the
kidney
• Hypertension
• Diabetic nephropathy
• Myelom
• Obstruction
• Analgesic nephropathy
• Systematic lupus
erythematosus
• Unknown aetiology