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L2 Dna and Genetics
L2 Dna and Genetics
DNA (deoxyribonucleic
acid)
This chemical substance is present in the nucleus
of all cells in all living organisms
controls all the chemical changes which take
place in cells
is a very large molecule made up of a long chain
of sub-units (NUCLEOTIDES)
Each nucleotide is made up
of :
• a sugar called deoxyribose
• a phosphate group -PO4 and
• an organic base
Ribose is a sugar, like glucose, but with only
five carbon atoms in its molecule
Deoxyribose is almost the same but lacks one
oxygen atom
PO4
adenine
deoxyribose
5
The bases
The most common organic bases are
Adenine (A)
Thymine (T)
Cytosine (C)
Guanine (G)
Joined nucleotides 7
PO4
A molecule of DNA is
PO4 formed by millions of
nucleotides joined
together in a long
PO4
chain
PO4
sugar-phosphate
+ bases
backbone
Bonding 1 10
Adenine Thymine
Cytosine Guanine
Pairing up 12
PO4
PO4
PO4
PO4
PO4 PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
PO4
REPLICATION
• The process of copying a DNA molecule to
make another DNA molecule
• • Each chain of nucleotides serves as a
template for a new, complimentary,
strand
• • Helicase – the enzyme complex that
separates nucleotide chains of DNA
• • The point of separation is called the
replication fork
• • DNA polymerase – enzyme that allows
complimentary nucleotides to build the
complimentary chains
• • 5 prime to 3 prime direction
• • Replication runs in opposite directions
16
STEPS OF replication
• Before a cell divides, the DNA strands unwind and separate
• Each strand makes a new partner by adding the appropriate nucleotides
• The result is that there are now two double-stranded DNA molecules
in the nucleus
• So that when the cell divides, each nucleus contains identical DNA
Making Proteins
JUNK DNA
• Segments of DNA
that are not parts of
genes
The Role of RNA in
Making Proteins
• tRNA(transfer RNA)
-are RNA molecules that translate mRNA into protein
• rRNA (ribosomal RNA)
-forms ribosomes, which are essential in protein
synthesis
Mutations
• SUBSTITUTION
• INSERTION
• DELETION
• DUPLICATION
Results of Mutation