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ONDANSETRON Presentation
ONDANSETRON Presentation
ONDANSETRON Presentation
Ondansetron 4 mg Tablets
Onda Syrup 30 ml
Each 5 ml contains 2 mg Ondansetron
Pharynx GUT
Cerebral Cortex
Liver CTZ
Vomiting Centre
Vomiting
Chemotherapy and
Radiation therapy
Chemoreceptor Trigger Zone
Vomiting
Release of 5-HT
Efferent fibers are those that travel away from the origin of the nerve, the
central nervous system (CNS).
• Vagus Nerve efferents from the brainstem to organs like the lungs, heart,
and those of the gastrointestinal tract. These fibers send signals that assist
in the control of those and other organs. These efferent fibers make up
about 10% of the Vagus Nerve.
The afferent fibers carry sensory information from the organs back to the
brainstem which is part of the central nervous system (CNS).
• Agonist
Drug or any substance that produce stimulation of
receptor
• Antagonist
That block the stimulation of(Sr.
Pabitra Thapa agonist
Product
Manager-MPD)
What are 5- HT3 receptor antagonists?
Category D Category X
There is positive evidence of Demonstrated fetal abnormalities
human foetal risk, but the in human and animals.
benefits from use in pregnant Contraindicated in women who
women may be acceptable are or may become pregnant.
despite the risk. Norgestrel, Warfarin, Nimesulide,
Tetracycline, Lorazepam Northisterone, Thalidomide