Aminouracil and

aminothiouracil as the
main pillar for
produce a variety of
heterocyclic systems
Presented by Abdalrhman
Mohamed Aboalkher
Amis
To identify how can prepare
aminouracil and aminothiouracil

To identify how can prepare

derivatives of aminouracil and
aminothiouracil
To identify how can prepare
aminouracil and aminothiouracil fuse
heterocyclic systems
 Contents
01. 02. 03.
introduction Syenthis of aminouracil Reactions of aminouracil and
and amino thiouracil aminothio uracil

03.a
Synthesis of substituted
03.b 04.
Synthesis of uracil-fused Conclusion
aminouracil aminothiouracil
heterocycles
derivatives
 01.
introduction
The great development in our lives requires production
of many compounds which has several uses as
antibiotics ,antiseptics, antiviral, anti cancer and other
compounds which used in many industries and
especially in the pharmaceutical field the N- containing
compounds especially pyrimidines structure offer and
easy way prepare many compounds especially uracils
derivatives the aminouracil and aminothiouracil which
is act a main pillar For preparation of many heterocyclic
systems
 02.
Syenthis of
aminouacil and
aminothiouracil
 03.
Reactions of
aminouracil and
aminothiouracil
 03.a
Syenthis of
substituted
aminouracil
aminothiouracil
derivatives
 N–
ALKYLATION

S-
ALKYLATIOJN

C –ALKYATION
 03.b
Syenthis of uracil-
fused heterocycles
 Overview Diagram classify the fused system according to number of
rings and number of hetereoatom
3 [6,5] system 4
3 [6,6,6,6] system

3 [6,6] system 4

3 [6,5,6,6] system

3 [5,6,6] system
3 [5,6,6,6] system
6 5

3 [6,6,6] system 4
Syenthis of bicyclic [6-
5] FUSED SYSTEM
 3 -heteroatom
Synthesis of pyrrolo[2,3-d] pyrimidines

Synthesis of thiazolo[3,2-a] pyrimidine

4- heteroatom
Synthesis of triazolo[4,3-a]pyrimidine
O O O O
Ph

NH NH2 O Ph
NH
HC NH N
DMF / REFLUX CH3COONa
+ N
8-10 h NH
H2N N S N
H H2N N N N H
H H2N
Syenthis of bicyclic [6-
6] FUSED SYSTEM
3 -heteroatom
Synthesis of pyrido[2,3-d] pyrimidine

4- heteroatom
Synthesis of pyrimido[4,5-d]pyrimidine
Syenthis of tricyclic [5-
6-6] FUSED SYSTEM
3 -heteroatom
Synthesis of cyclopenta[5,6]pyrido[2,3-d]pyrimidine

5- heteroatom
Synthesis of isoxazolo[4',5':5,6]pyrido[2,3-d]pyrimidine
Syenthis of tricyclic [6-
6-6] FUSED SYSTEM
 3 -heteroatom
Synthesis of pyrimido[4,5-b]quinolone

4- heteroatom
Synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(1H)-ones
5 -heteroatom
Synthesis of pyrido[2,3-d:6,5d']dipyrimidine

6- heteroatom
Synthesis of pyrimido[4,5-g]pteridine
Syenthis of tetracyclic
[5-6-6-6] FUSED
SYSTEM
3 -heteroatom
Synthesis of furo[3,2-g]pyrimido[1,6-a]quinazolin-3-one
Syenthis of tetracyclic
[6-5-6-6] FUSED
SYSTEM
 3 -heteroatom
Synthesis of indeno[2`,1`:5,6]pyrido[2,3-d]pyrimidine
Syenthis of tetracyclic
[6-6-6-6] FUSED
SYSTEM
3 -heteroatom
Synthesis of benzo[g]pyrimido[4,5-b]quinolintrione

4- heteroatom
Synthesis of chromeno[4',3':4,5]pyrido[2,3- d]pyrimidine
 04.
conclusion
At the end of this presentation we have learned about the
Great importance of aminouracil and aminothiouracil
and how it is very efficient compounds which can used
to produce many of heterocyclic compounds which not
easy to prepare by direct ways in good yields which it’s
Widespread in many application in our lives from
industries to our health care so it was a very important to
study about it
Thanks!
For dr/ mostafa el Sayed
for his great support
Thanks for your
listening