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Presentation 3
Presentation 3
In the early phase of infection, a positive PCR test may accompany a negative serological test, as it takes time for IgM
antibodies to develop.
In the convalescent phase, a positive serological test may accompany a negative PCR test.
For patients with suspected clinical features, the combination of PCR and IgM tests may be the most optimal approach for
early diagnosis, especially among pediatric patients.
Patients with suspected clinical features and one of the following three laboratory results may be diagnosed as having
acute mycoplasma infection:
1) Seroconversion (specific M. pneumoniae IgM from negative converse to positive).
2) An increase in specific antibody (two-fold increase in M. pneumoniae IgM or four-fold increase in specific IgG by titer or
dilution test) within a two-week interval.
3) Positive PCR results.
Tsai TA, et al. Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children. J Microbiol Immunol Infect. 2021;54(4):557-
565.
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