CARBOHYDRATES METABOLISM

CONTENT

 Carbohydrates metabolism
 Overview of Catabolic Processes
 Glycolysis
 Reaction and Regulation of Glycolysis
 CARBOHYDRATES
Carbohydrates are called carbohydrates because they
are essentially hydrates of carbon (i.e. they are
composed of carbon and water and have a composition
of (CH2O)n.
Carbohydrate metabolism is a fundamental biochemical
process that ensures a constant supply of energy to living
cells. The most important carbohydrate is glucose, which
can be broken down via glycolysis, enter into the Kreb's
cycle and oxidative phosphorylation to generate ATP.
V
CARBOHYDRATES METABOLISM
GLUCOSE TRANSPORT
 GLYCOLYSIS
• What is glycolysis?
Ten step metabolic pathway to convert glucose into two
molecules of pyruvate and two molecules each of NADH and
ATP.

• All carbohydrates to be catabolized must enter the

glycolytic pathway.
• Glycolysis is central in generating both energy and
metabolic intermediaries.
 The Glycolysis Pathway
• Major aerobic pathway in all cells
• NAD+ is the major oxidant
• Requires PO4
• Generates 2 ATP’s per glucose oxidized
• Connects with Krebs cycle via pyruvate
THE SIGNIFICANCE OF GLYCOLYSIS
• Glycolysis is the emergency – yielding pathway
• Main way to produce ATP in some tissues red
blood cells, retina, testis, skin, medulla of
kideney.
• In clinical practice
AEROBIC OXIDATION OF GLUCOSE
• Glucose oxidation
• Oxidation of glucose to pyruvate cytosol
• Oxidation of pyruvate to acetylCoA in mitochondria
• Tricarboxylic acid cycle and oxidative phosphorylation
SUMMARY
Carbohydrates are called carbohydrates because they are essentially
hydrates of carbon (i.e. they are composed of carbon and water and
have a composition of (CH2O)n.
Carbohydrate metabolism is a fundamental biochemical process that
ensures a constant supply of energy to living cells.
Glycolysis Ten step metabolic pathway to convert glucose into two
molecules of pyruvate and two molecules each of NADH and ATP.
The Glycolysis Pathway Major aerobic pathway in all cells
Requires PO4,Generates 2 ATP’s per glucose oxidized,Connects with
Krebs cycle via pyruvate
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