SCHOOL OF PHARMACY AND LIFE SCIENCE

HOSPITAL AND CLINICAL PHARMACY

PRESENTATION ON – RHEUMATOID ARTHRITIS

Dpharm 2nd year

Presented by-
Mrinal Shaw (Regd.no -191517100059)
Assigned by-
Pranay Das ( Regd.no191517100058)
Mr.Vivek Barik Chandana parida (Regd.no-191517100060)
(Assistant professor Pankaj Rath (191517100056)
SPCL CUTM) Rasananda Patra (Regd.no-191517100059)
DEFINITION

• Rheumatoid Arthritis is defined as a widespread,chronic

and inflammatory disease which affects the joints and
other organ system .
• In Rheumatoid arthritis the synovial membrane may
invade the joint space and the whole joint becomes
swollen and painful on movement.
EPIDEMIOLOGY
 The annual incidence of rheumatoid arthritis has been reported to be 40 per
100,000 .
Common disease having a peak incidence in the 3rd & 4th decades of life , with
3-5 high preponderance in females than in males .
The prevalance of RA in India is quiet similar to that reported from the
developing countries and is higher about 7 million patients in India .
 Approximately about 2 million Americans are affected by rheumatoid
arthritis .
CAUSES OF RHEUMATOID ARTHRITIS
Obesity
Age
Smoking
Autoimmune Condition
Synovium
Genetic Suspectability
Life-style Modification
• Hormonal Imbalance
SIGN AND SYMPTOMS
• Fatigue.
• Joint pain.
• Inflammation of joint
• Weight loss
• Joint swelling.
• Joint redness.
• Joint warmth.
• Joint stiffness.
• Loss of joint range of motion.
• Loss of appetite
 PATHOPHYSIOLOGY

It is an autoimmune disease. It is influenced by body

immunesystem reaction towards certain body proteins. As they
are foreign substances (antigens) and produce antibodies. It
has been observed that patient’s body considers human
gamma globuin (Igt) as the antigen and produces antibodies for
that rheumatoid factor. Ig M,Ig A, IgG are called as IgM
rheumatoid factor, IgA rheumatoid factor.
• Antigen reacts with antibody to form an immune complex
which then reacts with complement (proteins) and leads to
inflammation.
 PATIENT COUNSELLING

o Stay active always (exercise).

o Take the medications properly at correct time , dose as no
miracle cures will happen for RA .
o Do regular blood parameter monitoring .
o You should avoid food like fried & processed foods ,
AGE’s (heated,grilled foods) , sugar & refined carbs ,
dairy products , salt & preservatives , corn-oil etc .
o Eat more omega-3 foods (tuna , salmon , sardines ), egg ,
vitamin-D fortified milk products , organically grown
fruits and vegetables & extra-virgin oil .
TREATMENT
• Non pharmacological Treatment
• Diet
1. Exercise
2. Herbal Medicines
3. Massage
4. Stress Reduction Techniques- meditation, hypnosis, yoga.
5.
6.
7.
PHARMACOLOGICAL TREATMENT

• There are three types of medications used to treat RA:

1. Non-steroidal anti-inflammatory drugs (NSAIDs).
2. Disease-modifying anti-rheumatic drugs(DMARDS).
3. Corticosteroids