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SYCDW 2011 Coag Made Easy
SYCDW 2011 Coag Made Easy
V
X Factor V is a cofactor for
factor X, and you can
remember this because V
fits into the notch of the X
Coagulation made easy
V
X
Prothrombin Thrombin
Factor Xa converts prothrombin (Factor II) into
thrombin, the most important enzyme on the planet
Coagulation made easy
Prothrombin Thrombin
Fibrinogen Fibrin
The Common Pathway = Small Bills
V+X
II = prothrombin
I = fibrinogen
You can remember the factors in the common pathway by remembering the
bills in your wallet smaller than a $20. Don’t forget the $2 bill !!
Coagulation made easy - the PT
The PT Pathway
PT has one less letter than PTT,
and PT values are shorter than
PTT values, because the
pathway is shorter. It means 7
that the PT pathway is also
shorter. This means that there’s
V
fewer steps to remember, and
this is lucky, so the lucky PT
pathway uses lucky factor 7 to
X
activate factor X
Prothrombin Thrombin
Fibrinogen Fibrin
Coagulation made easy - the aPTT
The PTT Pathway
The PTT pathway has all those
XII hideous roman numerals. . .
IX V
VIII X
Prothrombin Thrombin
Fibrinogen Fibrin
Coagulation made easy - the aPTT
The PTT Pathway
E V
T X
Prothrombin Thrombin
Fibrinogen Fibrin
Coagulation made easy - the aPTT
The PTT Pathway
Twelve
Eleven
Nine
Eight V
Ten X
Prothrombin Thrombin
Fibrinogen Fibrin
Coag Made Easy: PT and PTT both Prolonged
Prothrombin (II)
Fibrinogen
Coag Made Easy: Only PT Prolonged
Deficiency of Factor VII will prolong the PT but not the PTT
Coag Made Easy: Only PTT Prolonged
Ten
XII What matters clinically
XI • Deficiencies of factor XI,
IX, VIII, VII. X, V,
IX
prothrombin and
VIII VII fibrinogen are clinically
significant.
X
• Inhibitors of these factors
V are clinically significant
for bleeding.
Thrombin • Deficiency of Factor XII,
Fibrinogen Fibrin and the presence of the
lupus anticoagulant are
not.
Coagulation Made Easy- The Mixing Study