Professional Documents
Culture Documents
Haematopoietic Agents & Erythropoeitin: Dr. Rishi Pal Assistant Professor Department of Pharmacology
Haematopoietic Agents & Erythropoeitin: Dr. Rishi Pal Assistant Professor Department of Pharmacology
Haematopoietic Agents & Erythropoeitin: Dr. Rishi Pal Assistant Professor Department of Pharmacology
Erythropoeitin
Dr. Rishi Pal
Assistant Professor
Department of
Pharmacology
Haematopoietic system
Erythrocytes
Leukocytes
Thrombocytes
Exogenous nutrients
Endogenous nutrients
Types of anaemia
Pallor
Fatigue
Dizziness
Exertional dyspnoea
Iron deficiency
Dietary deficiency
Faulty absorption, transport and storage
Excessive blood loss
Worm infestation
Max iron absorption: duodenum & jejunum
Haem iron & non haem iron (Fe+++)
Ascorbic acid, SH, Succinic acid facilitate
conversion of Fe+++ to Fe++ form
Anemia can be defined as a reduction in the
hemoglobin, hematocrit or red cell number.
Iron
Vitamin B12, Cyanocobalamin
Folic acid
Erythropoietin
• All body cells need iron. It is crucial for oxygen transport,
energy production, and cellular growth and proliferation.
Function of Haemoglobin:
Ferrous sulfate
Ferrous gluconate
Ferrous fumarate
PARENTERAL:
Iron Dextran
Iron-sucrose complex
Iron sodium gluconate complex
Treatment with oral iron should be continued for 3–4 months
after correction of the cause of the iron loss. This corrects the
anemia and replenishes iron stores.
• Postgastrectomy conditions
• Previous small bowel resection
• Inflammatory bowel disease
• Malabsorption syndrome
Iron-dextran: iv or im (50mg/ml)
Iron sucrose complex: iv or im
Iron-sodium gluconate: iv or im
Iron-sorbitol-citrate: only im
Iron dextran:
Cyanocobalamine
Hydroxycobalamine
Methylcobalamine
5’ deoxyadenosyl cobalamine
Cobalamine…
Pharmacokinetics of cobalamine
Intrinsic factor (IF)
Transcobalamine-II
Metabolic functions
Therapeutic uses
Daily requirement: 2-3 μg/day
Therapeutic dose: 100-1000ug/day i.m
Cobalamine…
Cyanocobalamine
REDISOL, MACRABIN 100µg, 500µg/day
Hydroxocobalamine
REDISOL-H, MACRABIN-H 500µg, 1000µg
per vial inj.
Methylcobalamine
METHYLCOBAL 500µg tab, NEUROKIND-
OD 1500µg tab., 500µg/ml inj.
Folic acid
Pteroylglutamic acid
Pharmacokinetics
Metabolic functions
Deficiency
Therapeutic uses
Daily requirement: 50µg
Therapeutic doses: 1-5mg/day
Folic acid
FOLVITE, FOLITAB 5mg tab
Folinic acid
RECOVORIN 15 mg tab., 75mg/ml, 10mg/ml
inj.
Haematopoietic growth factors