A Cute 5-part

BC-5000 Introduction
IVD International Marketing
Travis
 Principle

2 © 2012 Mindray Confidential

 DIFF Channel

Chemical dye, Flow cytometry and Laser scatter

DIFF Channel
Chemical dye Flow cytometry Laser scatter
Using different kinds Because of sheath Light scattering
of lyses to change the fluid, the blood cells occurs when a particle
properties of blood are passing through deflects laser light.
cells the counting aperture The extent to which
in single file. this occurs depends
on the physical
properties of the
particle.

Forward scatter (FS): cell volume

Side scatter (SS): cell granularity
 Tri-angle laser scatter

 LAS(Low angle scatter) ― Cell Volume

 MAS(middle angle scatter) ― Cellular Complexity
 WAS(Wide angle scatter) ― Cellular Granularity
DIFF Channel

RBC RBC

LAS

DIFF Lyse
LYM LYM

LAS
MON MON

WAS
NEU NEU

WAS
EOS EOS
DIFF Channel

LAS LAS
Cell Volume

Cell Volume
Complexity MAS
DIFF Lyse Complexity MAS

RBC RBC
LYM LYM
MON MON
NEU NEU
EOS EOS
DIFF Channel

MON%

NEU%

EOS%

LYM%
RUO interface

 Two scattergrams to distinguish Eosinophil and Neutrophil, in order

to improve the performance on high Eosinophil sample

Eosinophil
Flag

 WBC Abnormal LAS DIFF

 Immature cell?
LIC

 Abn/Atypical Lympho? LIC

 RBC Distribution Abnormal MON NEU

 Anemia ALY EOS

 HGB Abn/Interfere LYM

 PLT Distribution Abnormal

Nrbc

GHO

MAS
Baso/HGB Channel

RBC RBC

Other WBC
LH Lyse BASO

BAS BAS

Other
Other
WBC WBC
Baso/HGB Channel

HGB
MCH
MCHC

Fe 2+ Fe 3+
＋ Fe 2+
Fe 2+ Fe 3+
Fe 3+
Fe 2+ Fe 3+
Anionic surfactant
RBC/PLT Channel

DC Impedance
 RBC/PLT Channel

U=R*I
aperture When cell passing through the aperture
+ - by vacuum, it will introduce the change
on resistance. In a constant current, the
vacuum voltage change signal will be recorded
electrode
and accords with the volume of cell.

DC Impedance
Principle
Counting channels Reagents Technology Graphics Parameters

Chemistry dye; LYM

DIFF
1 channel
DIFF Lyse Flow cytometry DIFF Scattergram MON
NEU
Laser scatter EOS

RBC/PLT RBC histogram

2 channel Diluent Impedance
PLT histogram
RBC
PLT

Chemistry dye;
Flow cytometry BAS
3 Baso/HGB
channel
LH Lyse
Laser scatter Baso histogram WBC
HGB
Colorimetry
Parameters
* Research Use Only Parameter
RBC PLT WBC
MCV MPV LYM#
HCT PCT LYM%
RDW-SD PDW MON#
RDW-CV MON%
HGB NEU#
MCH NEU%
MCHC EOS#
EOS%
8 BAS#
BAS%

8 4 11
23 reportable parameters
 Selling points

17 © 2012 Mindray Confidential

 Mindray hematology portfolio
>400

Core laboratory
University hospital

CAL 8000

3-part 5-part
>240

Medium to
Large hospital
Samples per day

>120

BC-6800

Small to
Medium hospital
BC-5800

BC-5380

BC-5300
>60

BC-5150
BC-5000
Primary care
BC-3200
BC-3600 small hospital
BC-3000plus
BC-2800
BC-2300
>20

3 diff CBC+5 diff RET+NRBC Extended parameters

& automation line
Capability
 C ompact
UTE

19 © 2012Mindray Confidential
Compact size

320mm

410mm

400mm

20 © 2012Mindray Confidential
Compact size

30%

BC-5000 BC-2800 BC-5300

21 © 2012Mindray Confidential
Compact size

40%

BC-5000 XS-800i AcT 5diff

22 © 2012Mindray Confidential
Built in reagents

DIFF LH
Lyse Lyse
Diluent

23 © 2012Mindray Confidential
 C Utility
TE

24 © 2012Mindray Confidential
 10.4 inch LED touch screen

Similar interface with

BC-6800, 3600

25 © 2012Mindray Confidential
Utility – 3 counting modes

Whole blood mode (15μL)

Pre-diluted mode (20μL)

Capillary whole mode (15μL)

26 © 2012Mindray Confidential
Utility – unique capillary whole blood mode

1
40 µl
of
Blood
2 3160 µl
of
Diluent
4 5 6
Competitors’ pre-diluted mode

Mindray pre-diluted mode

Automatically dispense diluent

New capillary whole blood mode

Capillary blood collection

27 © 2012Mindray Confidential
Utility – flagging system

LAS DIFF WBC

LIC Large immature

LIC cells
LIC

MON NEU

ALY EOS

LYM Atypical lymphocyte

Nrbc

GHO

MAS

NRBC
Note: when NRBC exists, BC-5000 may flag “WBC abnormal”.

28 © 2012Mindray Confidential
 CU TE
echnology

29 © 2012Mindray Confidential
State-of-the-art technology
Cellular granularity
WAS: Wide angle scatter
(22-42 degrees)

Cell volume
LAS: Low angle scatter
(1-4 degrees)
Laser

Cellular complexity
MAS: Middle angle scatter
(6-20 degrees)

30 © 2012Mindray Confidential
Smart design

Innovative reaction system

Optimized liquid handling system

Innovative optical bench

Smaller, powerful

31 © 2012Mindray Confidential
3D cell analysis

Immature cell

Monocyte Neutrophil

Lymphocyte Eosinophil

Abn/Atypical
Lymphocyte

32 © 2012Mindray Confidential
Smaller counting aperture
Normal PLT Cell impulse
Intensity

PLT?
>80μm

Small PLT

Conventional counting aperture

Higher signal to noise ratio

Cell impulse
Normal PLT Intensity
PLT
50μm

Small PLT

BC-5000 counting aperture

33 © 2012Mindray Confidential
 C Ufficient
TE

34 © 2012Mindray Confidential
Built-in touch screen operation

35 © 2012Mindray Confidential
Low reagent consumption

Save

BC-5000 Competitor 1 Competitor 2 Competitor 3

36 © 2012Mindray Confidential
 Competitors

37 © 2012 Mindray Confidential

Global market share

2013
Global market size
2,7 billion USD
Product portfolio

XE-5000

XN-1000
XE-2100 XN-2000

HST system

PocH-100i

XT-4000i

XN-9000

KX-21N

XT-1800i
XT-2000i
XS-800i XS-500i
XS-1000i
Product portfolio

LH780
LH755

DXH 800
LH750

LH1500 Ac.T Diff

LH500

Ac.T Diff 2
Ac.T 5Diff CP

HmX Ac.T 5Diff OV

Ac.T 5Diff AL
Product portfolio

Pentra 120 Retic

Pentra DF 120
Pentra 120

Pentra DX 120
Pentra XL 80

Pentra DX 120 SPS

Micros 60
Pentra 80

Micros ES 60

Pentra 60 C+
Pentra 60
 Thank You!

Thank you!