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Parasite and Infection
Parasite and Infection
Parasite and Infection
Type of relationships
Symbiosis:
Is the relationship between two unsimilar organisms that are adapted to living together,
and the associates called symbionts. This association may be beneficial or harmful to
either of the association.
Mutualism:
Is termed to symbiotic association that is beneficial to both parties.
Commensalism:
Is the relationship when one of the associated organisms is benefited and the other is
neither benefited nor harmed.
Parasitism:
Is the relationship when one (the parasite) lives in or on the other at the expense of the
latter (the host).
The parasite:
Is the organism which depends on other living organism in its feeding, housing, and
transportation, this organism called (the host). The host may either not be harmed or may
suffer the consequences of this association, a parasite disease.
*The successful parasite should reach a precise equilibrium with its host so that each
tolerates the other. If the balance is disturbed, the host may spontaneously expel or
destroy the parasite, or, on the other side, the association may become so harmful to the
host which lead to the infection and the parasite deposit as a consequence.
*Parasites that cause harm to the host called pathogenic parasites while those that
benefit from the host without causing any harm to their hosts known as commensals.
Ectoparasites:
Are organisms that live on or in the skin of their hosts, and the relationship called
infestation. Most parasitic arthropods belong to this category.
Endoparasites:
Are the parasites of the digestive tract, extraintestinal organs and tissues, and those that
are intracellular within the host, and produce infection, irrespective of their size.
Obligate parasites: the parasites that are entirely dependent on their hosts.
Paratenic host: is the host in which the parasite is transported and neither gains nor loses
infectivity for its definitive host.
Vectors: are transmitters of parasites from host to host. If the transmitter is not essential to
the life cycle, it is a mechanical vector; if it is essential, it is a biologic vector.
Reservoir host:
Is an animal species on which the parasite depends for its survival in nature and serves as a
source of infection for other susceptible host, including man.
Zoonosis: is the term applied to a disease of animals when it is transmitted to man; this
may be a common or an incidental occurrence.
*Parasites that injure their hosts called pathogens, while the development of this damage
is pathogenesis.
The degree of injury to the host depends on variety of
factors, including:
• Toxic.
• Allergic in nature
*In other instances the host may generate specific antibodies that counteract the antigens
introduced by the foreign agent, or may wall off the invader or its products by cellular
infiltration, proliferation and differentiation.
*The host response may be essentially local at the site of injury or it may include system
humoral or cellular changes.
*A person may carry a parasitic infection that is transmissible to others, yet himself
show no related signs or symptoms. This person is called a carrier.
Epidemiology
• It is the science concerned with the factors that determine the prevalence of infection and the incidence of disease.
• It is the history of the disease, including infection in man and animals and agents that serve as reservoirs and vectors.
• Prevalence:
• Representing the number of infected individuals at a given time in a designated area.
• Incidence:
• Is the rate or frequency a disease (new infection) occurs.
• *If the infection appears irregularly in scattered individuals, it is sporadic; and if it develops a high prevalence
through unusually rapid transmission, it is epidemic.
• Many examples on parasitism are found among the groups of lower organisms, such as the viruses, rickettsiae,
bacteria, fungi and spirochetes. However, parasitism varies widely with respect to the degree of adaptation,
Parasitic infections, Pathogenesis and
immunity
• The cysticerci can be found in the muscle, liver, eye or, most dangerously, the brain.
• Hydatid cysts, the larval stage of the dog tapeworm (Echinococcus granulosus) in man, may reach
volumes of 1–2 L, and such masses can cause severe damage to an infected organ.
• Another type of pathogenicity may be represented by the physiological effects. The large numbers of
Giardia spp. covering the walls of the small intestine can lead to malabsorption, especially of fats.
• Competition by parasites for essential nutrients leads to host deprivation. Thus, depletion of vitamin
B12 by the tapeworm Diphyllobothrium latum sometimes leads to anaemia.
• Immunoparasitology: is a branch of immunology that deals with the human parasites and their hosts
immune response.
• Immunopathology: Many helminth parasites are long-lived and causes chronic infections. The
immune response that develops during this time often proceeds to cause pathologic changes that in
many helminth infections are the primary cause of disease. A well-studied example of this is the
granulomatous reaction that isolate schistosoma eggs.
Cysticercosis
Echinococcosis
Giardia spp
Immune responses that prevent infection with helminths