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    Ebolavirus is a genus of virus that causes severe hemorrhagic fever in humans and non-human primates. There are six known ebolavirus species that can cause disease in humans. Symptoms include fever, vomiting, diarrhea and internal and external bleeding. Treatment involves isolation, hydration and supportive care. Vaccines have been developed for the Zaire species of ebolavirus. Major outbreaks have occurred in Africa since 1976, with the largest being the 2014-2016 outbreak across West Africa that caused over 28,000 cases and 11,000 deaths.

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    Ebolavirus is a genus of virus that causes severe hemorrhagic fever in humans and non-human primates. There are six known ebolavirus species that can cause disease in humans. Symptoms include fever, vomiting, diarrhea and internal and external bleeding. Treatment involves isolation, hydration and supportive care. Vaccines have been developed for the Zaire species of ebolavirus. Major outbreaks have occurred in Africa since 1976, with the largest being the 2014-2016 outbreak across West Africa that caused over 28,000 cases and 11,000 deaths.

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    4 views15 pages

    Report 1

    Uploaded by

    edan Marvil
    Ebolavirus is a genus of virus that causes severe hemorrhagic fever in humans and non-human primates. There are six known ebolavirus species that can cause disease in humans. Symptoms include fever, vomiting, diarrhea and internal and external bleeding. Treatment involves isolation, hydration and supportive care. Vaccines have been developed for the Zaire species of ebolavirus. Major outbreaks have occurred in Africa since 1976, with the largest being the 2014-2016 outbreak across West Africa that caused over 28,000 cases and 11,000 deaths.

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    of 15

    Ebolavirus

    Ebolavirus(genus)
    Family: Filoviridae 6 Species:
    o Zoonotic virus Zaire ebolavirus
    Sudan ebolavirus
    Taï Forest ebolavirus
    Bundibugyo ebolavirus
    Reston ebolavirus
    Bombali ebolavirus
    Symptoms
    Diarrhea

    Rashes
    Fever

    Vomiting

    Hemorrhages
    Treatment
    Isolation
    Proper Hydration
    Oxygen therapy
    Treatment for other infections
    Vaccine
    • rVSV-ZEBOV or Ervebo
    Only against Zaire ebolavirus
    FDA approved (12/19/2019)

    • Ad26.ZEBOV and MVA-BN-Filo


    Also for Zaire ebolavirus
    Earliest recorded cases
    1976
    Ebola Outbreaks 1976-2014
    1996
    highest 2008 – 2012
    1994 reported 2001- 2003
    Total cases 120 total
    Tai Forest cases: 60
    of 302 cases
    Gabon & Cote Gabon &
    Gabon & DR of Congo DR of Congo Zaire ebolavirus
    d’lvoire South Africa & Uganda

    1976 -1979 1995 2000 2004 – 2007 2014


    Discovery of More than 425 cases New Ebola species: More than 15000
    Sudan and Zaire 300 cases Uganda Bundibugyo cases
    Ebolavirus Sudan & DR of Congo Sierra Leone,
    DR of Congo Liberia, Nigeria,
    DR of Congo &
    Sudan Senegal, Mali,
    Guinia & DR of
    Congo
    2014 -2016 Outbreaks
    Countries with Widespread Total Cases (Suspected, Laboratory Confirmed
    Transmission Probable, Confirmed) Cases Total Deaths
    Guinea 3,814 3,358 2,544
    Liberia 10,678 3,163 4,810
    Sierra Leone 14,124 8,706 3,956
    Affected Countries
    Italy 1 1 0
    Mali 8 7 6
    Nigeria 20 19 8
    Senegal 1 1 0
    Spain 1 1 0
    United Kingdom 1 1 0
    United States 4* 4 1
    Total 28,652 15,261 11,325
    2018
    Ebola virus disease cases by week. Data as of 14 January
    2020
    April 19th Update

    Total Cases Confirmed Total Deaths Survivors


    cases
    3404 3,316 2,242 1,165
    Ebolavirus (structure)
    Only has 7 Genes to create
    the proteins needed for
    survival and replication.
    Coat
    Cell attachment & Invasion

    Serves different function with


    3 configurations

    Binds/ Organizes the Viral


    RNA into a Rod shape

    Maintains the structure of


    nucleocapsid
    Suppresses the immune
    system

    RNA polymerase
    Makes copies of viral RNA
    with VP35
    Matrix protein VP40
    Hexamer
    Forms
    filamentous
    matrix for
    replication

    reconfigured

    Cyclic Octamer
    Viral Replication Dimer
    Transports the
    element of
    nucleocapsid into
    the host cell
    References
    • https://www.youtube.com/watch?v=UMMwgvLmN-M
    • https://www.cdc.gov/vhf/ebola/history/2014-2016-outbreak/index.htm
    l
    • http://publichealthintelligence.org/content/chronology-ebola-virus-dise
    ase-outbreaks-1976-2014
    • https://www.ecdc.europa.eu/en/all-topics-z/ebola-and-marburg-fevers/
    threats-and-outbreaks/ebola-outbreak-DRC-geographical-distribution
    • https://www.who.int/emergencies/diseases/ebola/drc-2019
    • https://www.britannica.com/science/ebolavirus
    • http://pdb101.rcsb.org/motm/178
    • https://www.youtube.com/watch?v=9SptF9bCyd0
    • https://www.cdc.gov/vhf/ebola/prevention/index.html
    • https://www.who.int/csr/don/16-january-2020-ebola-drc/en/

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