Appendiceal Goblet Cell

Adenocarcinoma
A Historically Informed Reading of 6 Cases

Presented By:
Dr. Mina Amer
Post Graduate Resident, Histopathology.
Context:

 Appendiceal goblet cell adenocarcinoma is an uncommon

appendiceal neoplasm that is typically diagnosed
incidentally to a presentation of acute appendicitis. Over
the years, there have been many changes to the histologic
evaluation and classification of this neoplasm, culminating
in the most recent (2019) World Health Organization
recommendations.
Objective:

 To understand the evolution of the concept of ‘‘goblet

cell’’ neoplasia in the appendix, we explore a series of
cases of goblet cell adenocarcinoma encountered at a
county hospital over a 20-year period. We performed a
historically informed review of these cases to highlight the
significance and blind spots of our current definition and
approach to this disease entity.
Data Sources:

 The cases were recovered from the archives of a county

hospital (1999–2019). The literature was assembled
through PubMed searches on the various names given to
‘‘goblet cell’’ neoplasms since the 1970s. We also refer to
standard reference books of gastrointestinal pathology.
Conclusions:

 Frequent and numerous changes in the nomenclature of

‘‘goblet cell’’ lesions of the appendix resulted in
considerable confusion regarding the approach to this rare
entity, especially pertaining to its grade, as well as to its
management in the clinical setting. The newest approach,
recommended by the World Health Organization, provides
clarity to its pathologic and clinical management. Adherence
to these recommendations will improve communication
between pathologists, surgeons, and oncologists about the
natural history and prognosis of this malignant neoplasm.
Thank you for your
participation