QUALITY CONTROL

EVALUATION AND METHOD OF DEVELOPMENT OF

ASPIRIN

PANDEY AJAY SANJAY

B.PHARMA 4th year
R.I.T.M LUCKNOW
ROLL NO:1820350065
SUBMITTED TO: Dr. YASMIN KHATOON
 TABLE OF CONTENT

• General introduction of aspirin

• Evaluation of aspirin tablet
• Assay of aspirin
• Method of development of aspirin
• References
 GENERAL INTRODUCTION OF ASPIRIN
• GENERIC NAME: Acetylsalicylic acid
• Classified in british formulary as NON STEROIDAL
ANTIINFLAMATORY DRUGS.
• CHEMICAL FORMULA: C9H8O4
• Average molecular weight: 180.15g/mol
• SYNONYMS: Acidum acetylsalicylicum, Apirina.
• MOA: Inhibitis prostaglandins synthesis, by inhibiting
COX-1 AND COX-2 enzymes.
• IUPAC NAME: 2-(acetyloxy)benzoic acid
 GENERAL INTRODUCTION OF ASPIRIN
• MELTING POINT: 1350C
• USES:
• Anti inflammatory
• Anti platelets
• Fever
• Cardio vascular disease
• Myocardial infraction
• Transient ischemic
attacks (TIA)
 EVALUATION PARAMETER OF ASPIRIN
• Drug evaluation may be defined as determination of identiy,
quality of drug.
• WEIGHT VARIATION: MEAN= 175.7mg
• FRIABILITY: 1) 2.7unit weight 2) 1.85 unit weight 3) 2.7 unit
weight
• HARDBNESS:3.5+3.6+3.6+3.8+8+3.9= 3.066 kg/cm2
• DISINTEGRATION ( DT TIME) 10+9+10=29/3=9.6 min
• DISSOLUTION: PASSED
 ASSAY OF ASPIRIN

• 15g of Acetyl salicylic acid dissolve in 15ml of ethanol.

• Add 50ml of 0.5 M NaOH.
• Boil for 10 minute and then cool.
• Titrate excess of alkali qwith 0.5M HCL using phenol
red solution as indicator
• Difference between titration represents amount of
NaOH required.
 ASSAY OF ASPIRIN GASTRO-RESISTANT TABLETS

• 20 Tablets weighed and powdered.

• powder containing 0.5g of aspirin weighed and
powdered.
• 30ml of 0.5M NaOH is added and boiled upto 10
minute.
• Allowded for cooling and titrated with 0.5M HCL by
adding phenol red indicator.
 METHOD OF DEVELOPMENT OF ASPIRIN

• Drug development is the

process of bringing a new
pharmaceutical drug to the
market once a lead
compound has been
identified through the
process of drug discovery.
 REFERENCES
• https://en.wikipedia.org/wiki/Drug_development
• https://pubchem.ncbi.nlm.nih.gov/compound/Aspirin
• Leon Lachman book of industrail pharmacy.