CAR T-cell therapy +

somatic Vs germline gene

therapy + Ethics of human
genome-editing.

Ehad albusaidi
20191464
•somatic Vs germline gene therapy
Somatic
targets body tissues. These cells do not
produce sperm or eggs. therefore, the
gene is not transferred to the next
generation.

targets germinal or reproductive cells.

These cells produce male and female
gametes therefore the inserted gene
germline passes to the future generations. The
transfer can also be done during early
embryonic development,, then the desired
gene can be inserted in all the cells of a
developing embryo.
In vivo Ex vivo
Somatic :A single gene disorder
like hemophilia, thalassemia,
cystic fibrosis, etc. have good
chances of being cured by
somatic cell gene therapy

Germline :more effective and can

be a permanent cure for genetic
diseases that run-in families. It has
the potential to eliminate a disease
from the population. But it is not yet
legal in many countries due to
ethical issues. Some people may
use it for enhancements rather than
treatments. There is also insufficient
knowledge of risks posed to the
future generations.
•How its done ?
 CAR T –cell therapy :
Chimeric antigen receptor (CAR) T-cell therapy is a way to get immune cells
called T cells (a type of white blood cell) to fight cancer by changing them in
the lab so they can find and destroy cancer cells. CAR T-cell therapy is a type
of cell-based gene therapy, because it involves altering the genes inside T cells
to help them attack the cancer.

How CAR T-cell therapy works ?

•thank you for listening :
Resources