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1.2 URTI Approach
1.2 URTI Approach
1
URTIs : inflammation of the respiratory
mucosa from the nasal cavity down to the
bronchus. (above the level of the carina).
Includes : common colds , influenza ,
sinusitis , rhinitis , tonsillitis , otitis media ,
pharyngitis , laryngitis,epiglottitis,Tracheitis
and croup.
Epidemiology:
In average , children will have 5 URTIs/ year
and adults 2-3/year.
70-80 % of these infections are caused by
viruses ; rhinoviruses and adenoviruses are
the most common.
3
Management principles:
*Viral infections need ONLY symptomatic
treatment , NO need for antibiotics(Abs).
Viral URTIs :
1. Influenza
2. Common cold
4
*Bacterial infections need ABs for treatment
in addition to the symptomatic treatment.
Bacterial URTIs :
1. GABHS pharyngitis
5
*Why not to use Abs for viral infections ?
1. Promotes Abs resistance.
4. costly
6
Why to use Abs for bacterial infections?
1. To prevent suppurative complications
3. To speed up recovery
7
Common cold( nasopharyngitis )
8
Common cold is a self-limiting , viral
infectious disease of the upper respiratory
system.
Incidence : most frequent infectious disease in
humans ; 2-4 infections / year in adults and 6-
12 in children.
Transmitted by droplets and close personal
contact / airborne.
usually occurs in the fall and winter months.
9
Causative agents :
Rhinovirus (50%) , coronavirus (10-20%),
adenovirus (5%) , others :RSV , parainfluenza virus.
Bacterial infections are unlikely:
Mycobacterium leprae, Klebsiella
rhinoscleromatis, Pseudomonas mallei
(glanders), Rhinosporidium seeberi
(rhinosporidiosis), Leishmania mexicana
(leishmaniasis)
10
Symptoms:
The first symptom is usually a sore or “scratchy
throat” , followed soon after by nasal stuffiness and
discharge ( rhinorrhea ) , sneezing and coughing.
The throat is usually sore for a brief time. The cough symptoms are
usually worse on the 4th or 5th day of illness , while the nasal
symptoms improve.
Symptoms generally last for 7 to 10 days.
Cough may continue up to 4 weeks.
11
If the nasal discharge becomes viscous and
green with time ; it doesn’t mean
superimposed bacterial infection . It’s a
normal course of common cold.
12
Complications:
1. Acute otitis media (most common in children)
2. Pharyngitis
3. Sinusitis
5. Conjunctivitis
6. Adenitis
7. Aggravation of asthma
13
Management:
Symptomatic Treatment :
comfort is the goal of treatment which may
include:
*nasal suction for infants
*steam/mist inhalation
*nasal irrigation
*humidified air
14
*consume extra fluids (warm fluids may be
soothing for irritated throats
*consume nutritious diet as tolerated
*elevate head of bed
*salt water gargle for sore throat with
homemade salt water (1/4 teaspoon dissolved in
8 ounces warm water)
*get adequate rest
15
*VitaminC may reduce duration of
common cold in children.
16
Medication :
1. Antipyretics: no evidence that
fever or antipyretic treatment affects
illness course or neurologic
complications:
2. Ibuprofen appears more effective
than acetaminophen for reducing
fever in single-dose comparisons
and ibuprofen and acetaminophen
appear to17
have similar analgesic
effects .
*Combined or alternating
acetaminophen and ibuprofen
regimens may be more effective than
either monotherapy for reducing
fever in children.
*Ibuprofen approved for use( by FDA)
after 6 months of age.
*Paracetamol: may be used after 2-3
months of age.
18
Nasal Decongestants and Antihistamines:
*Nonprescription medicines (antihistamines
and antitussives) do not appear effective for
acute cough in children )
*FDA recommends against use of nonprescription cough and cold
products in children < 2 years old and supports not using them in
children < 4 years old.
*nonprescription cough and cold preparations may not be safe
in children
19
*Aspirin is contraindicated in children
with viral infections due to association
with increased risk for
Antibiotics :
*Abs do not appear to reduce symptoms of common
cold or acute purulent rhinitis.
* No role of antibiotics in common cold ( viral infection ).
20
Prevention:
*Wash hands after contact with common cold
patients.
*Do not touch any surfaces or objects that may
have been contaminated.
*Keep fingers out of eyes and nose.
21
Influenza:
*Influenza is a viral infection that affects
mainly the nose , throat , bronchi , and
occasionally lungs.
22
Seasonal influenza
*Acute viral infection caused by influenza type A , B and C.
*Type A and B are constantly changing due to mutations
( antigenic drift and shift ) , more serious than type C.
*Type C is stable , it’s cases occur much less frequently than
type A and B.
*Currently influenza A (H1N1) and A (H3N2) subtypes are
circulating among humans.
*Transmitted by droplets and close person contact /
airborne.
23
Signs and symptoms
*Following an incubation period of 1-2 days, flu presents with abrupt
onset of fever (39 – 40 c) ,muscle aches , headache and fatigue. The
individual may have respiratory symptoms such as a dry cough , sore
throat , and occasionally a runny nose.
24
Prognosis:
These symptoms generally improve over two to five days, though may
last one or more weeks.
* A dry cough (post viral cough syndrome) may also persists for several
weeks.
25
Common cold Vs Influenza:
26
Complications
1. Bronchitis
2. Sinus infections
3. Ear infections
4. Pneumonia
5. Encephalitis
27
Highest risk of complications occurs among :
28
Treatment:
1. Bed rest
2. Antipyretic/Analgesics
3. Fluid intake
29
4-Antiviral treatment:
antiviral treatment recommended as soon as possible (and not
delayed while awaiting diagnostic confirmation) for patients with
confirmed or suspected influenza who:
*have severe, complicated, or progressive illness
*require hospitalization
*are at higher risk for influenza complications
1. - children < 2 years,
2. -adults ≥ 65 years ,
3. -pregnant women ,
4. -chronic medical illnesses ,
5. -immunocompromised patients
adults
zanamivir 10 mg (2 inhalations) twice daily for 5 days;
not recommended in patients with airways disease
oseltamivir 75 mg orally twice daily for 5 days
peramivir 600 mg IV single dose
children
zanamivir 10 mg (2 inhalations) twice daily for 5 days
for children ≥ 7 years old
amantadine 5 mg/kg/day (maximum 150 mg/day) in 2
divided doses for 5 days for children aged 1-9 years
oseltamivir
Prevention:
1. Frequent hand washing.
afebrile period.
4. Vaccination ; most effective measure of
prevention .
32
Influenza vaccine
Annual vaccine
Two types :
1. Injectable : killed vaccine
2. Nasal spray : live but weakened virus
33
Recommended for :
1. *all persons ≥ 50 years old
2. *Infants and children aged from 6 months to 4 years.
3. *women who are or will be pregnant during the influenza season.
.)
34
*household contacts and caregivers of children < 5 years old.
36
Pharyngitis/Tonsillitis:
38
Bacterial Vs. Viral
*Viral Infection:
-Clinically: Gradual, more likely to have rhinorrhea, cough, diarrhea,
hoarseness of voice.
40
41
Age-modified Centor score (McIsaac
score):
1 point for each of
tonsillar exudate
swollen tender anterior cervical nodes
absence of cough
history of fever or measured temperature > 38 degrees C
(100.4 degrees F)
age modification
1 point if age < 15 years
-1 point if age > 45 years
43
Why we treat GAS pharyngitis
*decrease risk of Rheumatic fever, but not of PSGN.
44
Diagnosis of Sore Throat:
Rapid Antigen Test (RAT)
Sensitivity of RAT against culture varies between 61-95%.
Specificity of RAT 88-100%
Throat Culture
20-40% of those with negative throat culture will be labeled as
having GABHS.
+ve culture makes the Dx of GABHS,
45
1. Differential diagnosis -
2. Infectious mononucleosis, when a membranous exudate is
present.
6. - Kawasaki disease.
46
Complication of GAS pharyngitis:
1- otitis media
2- Glomerulonephritis and Rheumatic Fever may follow
streptococcal infection.
3- Monoarthritis.
4- Mesenteric adenitis (viral or bacterial) abdominal pain
with or without vomiting.
5- In debilitated children, large chronic ulcers in the
pharynx (viral or bacterial).
47
According to revised Jones criteria, the
Rheumatic Fever diagnosis of rheumatic fever can be
Major Criteria: made when:
- Polyarithritis 2 major criteria, or 1 major criterion
- Carditis plus 2 minor criteria, are present along
with evidence of streptococcal
- Sydenham Chorea infection: (elevated or rising ASO titre or
- Subcutaneous nodules DNAase).
49
Bacterial Pharyngitis:
Antibiotics:
Penicillin: 10 days oral or once IM.
safe , cheap , narrow spectrum , no resistance
Symptomatic:
Antipyretics/ Analgesia: paracetamol.
50
Surgery (tonsillectomy )
Surgery to remove tonsils (tonsillectomy) may be used to treat
frequently recurring tonsillitis, chronic tonsillitis, or bacterial
tonsillitis that doesn't respond to antibiotic treatment.
52
Sinusitis:
Inflammation of mucosa of
paranasal sinuses.
53
Sinusitis:
Risk Factors:
Allergic rhinitis or hay fever
Cystic fibrosis.
Day care, Weakened immune system from HIV or chemotherapy
Changes in altitude (flying or scuba diving)
Large adenoids, Nasal polyps
Smoking
Nasogastric and nasotracheal intubation
54
*Clinical presentation
*The symptoms of acute sinusitis in adults usually
follow a cold that does not improve, or one that
gets worse after 5 - 7 days of symptoms.
*Symptoms:
Mucopurulent Rhinorrea
Nasal congestion
Facial pain, pressure and fullness
Decrease sense of smell
Exam:
Looking in the nose for signs of polyps
Shining a light against the sinus (transillumination) for
signs of inflammation
55
Tapping over a sinus area to find infection (tenderness),
very painful
Diagnosis of Sinusitis:
Clinically
We use radiological evaluation if there is warning signs:
Brain abscesses
57
Treatment of Sinusitis:
*Analgesics and antipyretics as needed
*Intranasal corticosteroids.
*Consider intranasal saline with either
physiologic or hypertonic saline.
*Decongestants and antihistamines: lack evidence
for effectiveness unless evidence of allergic
component.
58
*antibiotics for acute bacterial sinusitis:
-most cases resolve without antibiotic treatment.
-only consider treatment with antibiotics if patient meets criteria for
acute bacterial sinusitis.
consider watchful waiting without antibiotics in patients with
uncomplicated mild illness (mild pain and temperature < 101 degrees F
[38.3 degrees C]) with assurance of follow-up .
*if decision made to treat with antibiotics, amoxicillin is first-line therapy
for most patients
59
Criteria for acute bacterial sinusitis:
60
Preventing Sinusitis;
gently blowing your nose, blocking one nostril while blowing
through the other
drinking plenty of fluids to keep nasal discharge thin
avoiding air travel. If you must fly, use a nasal spray
decongestant before take-off to prevent blockage of the
sinuses allowing mucus to drain
If you have allergies, try to avoid contact with things that
trigger attacks. If you cannot, use over-the-counter or
prescription antihistamines and/or a prescription nasal spray
61
Otitis Media
62
Suppuratice or acute otitis media (AOM):
Mainly caused by Strep. Pneumoniae, non typeable H. influenza,
M. catarrhalis.
Virusis: mainly Rhinovirus and RVS (30%)
Non-suppurative or secretory otitis media or otitis media with
effusion (OME)
Usually non infective
Cultures are sterile, but in 30% same organisms
Recurrent otitis media
3 times in 6 months or more than 4 times in a year
Chronic otitis media
Foul-smelling otorrhea.
63
Risk factors:
Age: 6-20 months- decrease with age
Male gender
Low socioeconomic status
Exposure to smoking and day care attendance
More in cold weather
Bottle feeding while sleeping, breast feeding (protective)
Congenital anomalies: Down syndrom, cleft palate.
64
Clinical Presentation:
In infants, are nonspecific and include fever, irritability,
excessive crying and poor feeding.
In older children and adolescents, fever, otalgia (acute ear
65
Acute Otitis Media:
Acute symptoms and signs or Middle Ear
inflammation with Middle Ear Effusion.
Middle Ear Effusion:
Bulging of the tympanic membrane.
Otorrhea
Distinct otalgia
1. Shiny
2. Translucent.
3. +ve light reflux
4. No air fluid border
5. No bulge.
67
Red bulging TM
Red, bulge, distortion of
normal landmarks, loss of the
cone of light.
68
Acute otitis media
Redness
69
Bulging
Complication of Otitis Media :
Chronic suppurative otitis media
Acute mastoiditis
Facial paralysis
Cholesteatoma (cyst like lesion in middle ear, tend to expand and
cause bone resorption)
Intracranial complications: meningitis, abscess, lateral sinus
thrombosis
Conductive hearing loss and possible developmental sequelae
70
How to manage it?
Natural history of OME is spontaneous resolution … days-
months.
• Prompt surgical referral for structural damage to TM or ME
(e.g. cholesteatoma).
• Surgical referral for children with OME with hearing loss
independent on OME, speech or language disorder,
developmental delay and uncorrectable visual impairment.
• Antihistamines, decongestants, or steroids are not used in
the management of OME in children.
71
Treatment of Otitis Media:
Give drugs to decrease pain (oral-topical analgesics)
Antibiotics :Indications:
moderate or severe otalgia
otalgia for ≥ 48 hours
72
Choice:
Amoxicillin 90mg/kg/days
Amoxicillin 45mg+amoxiclav 45mg
73
If the patient fails to respond to the initial management
option within 48-72 hours, clinician must reassess to confirm
AOM and exclude other causes of illness. If AOM is confirmed
in:
Patient initially managed with observation, begin
antibacterial therapy.
Patient initially managed with antibacterial agent, change
the agent.
If treatment failed: tympanocentesis and culture may be
needed
Clinician should encourage the prevention of otitis media
74
Croup
75
Croup:
LaryngoTracheoBronchitis
Caused by ParaInfluenza virus
Age: 3 months – 5 years, peak 2 year
More in male
More in Winter
76
Clinical presentation:
Some Rhinorrhea, mild cough, low grade fever,
1-3 days then characteristic barking cough, hoarseness and
inspiratory stridor (70% obstruction)
Worse at night, usually resolve in 1 week.
77
Diagnosis of Croup:
diagnosis is usually based on history, physical, and response
to treatment.
sudden onset of barking cough, hoarseness, and inspiratory
stridor in a child (especially if aged 6-36 months)
absence of atypical findings (for example, wheezing, drooling,
or toxic appearance)
78
Treatment of Croup:
Airway management is the priority:
Use cool mist
79
Complications:
respiratory distress
Epiglottitis
Bacterial trachetitis
Prevention:
Immunication for influenza and parainfluenza
virus.
80
Epiglottitis
81
Epiglottitis:
Epiglottitis is inflammation of the tissue that covers the trachea
(windpipe). It is a life-threatening disease.
Caused by H. Influenzae, S. pneumoniae, S. aureus
82
Clinical Presentation:
Epiglottitis begins with a high fever and sore throat.
Dyspnea, progressive upper airway obstruction in hours.
83
Diagnosis:
Clinical
Large cherry red swollen epiglottis by
laryngoscope
Lateral neck x-ray: thumb sign
(swollen epiglottis)
84
Treatment of Epiglottitis:
It is a Medical Emergency : establish airway by
intubation, rarely tracheotomy regardless of the
degree of obstruction.
Antibiotics: broad-spectrum second- or third-
85
Laryngitis
86
Is one of the most common conditions
identified in the larynx.
An inflammation of the larynx, manifests in
both acute and chronic forms.
Acute : less than 3 weeks
Chronic : last more than 3 weeks
Acute laryngitis has an abrupt onset and is
usually self-limited. If a patient has
symptoms of laryngitis for more than 3
weeks, the condition is classified as chronic
laryngitis. The etiology of acute laryngitis
includes vocal misuse, exposure to noxious
agents, or infectious agents leading to upper
respiratory tract infections. The infectious
agents are most often viral but sometimes
bacterial
87
Causes:
Infection (usually viral upper respiratory tract
infection) Rhinoviruses
Parainfluenza viruses
Respiratory syncytial virus
Adenoviruses
Influenza viruses
Measles virus
Mumps virus
Bordetella pertussis
Varicella-zoster virus
Gastroesophageal reflux disease
Environmental insults (pollution)
Vocal trauma88
Use of asthma inhalers
Generally associated with hoarseness or loss of voice.
Symptoms: hoarseness of the voice
Fever
Swollen lymph nodes
Patients with laryngitis may also experience odynophonia,
dysphagia, odynophagia, dyspnea, rhinorrhea, postnasal
discharge, sore throat, congestion, fatigue, and malaise.
Complications: rarely respiratory distress
Treatment: no role of antibiotics, symptomatic
treatment (pain killer, decongestant)
89
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