Aerobic & Anaerobic

Respiration

Chapter 25 pp. 940-941, 943-951

Chapter 10 pp. 309-310
 Reinforcing Assignments

 THQ - Cellular Respiration

 On WileyPlus
Do: Animation: Cell Respiration &
Animations Review Sheet
Metabolism
 Catabolic reactions  Anabolic reactions
• decomposition • synthesis
• exergonic • endergonic
ATP
 ADP + P
energy ATP

 ATP ADP + P + energy

 Glucose Transport
 Facilitated diffusion through GluT molecules
 Number of GluT molecules regulated by
insulin
• except liver cells and neurons where GluTs
always present
 Glucose phosphorylated after entry so can’t
leave
• Except liver cells
Aerobic/Cellular Respiration
Overall chemical equation:

C6H1206 + 6 O2 = 6 CO2 + 6 H20 + 30-32 ATP

(glucose)
 Aerobic Cellular Respiration -
Overview
 Glycolysis

 Formation of Acetyl
CoA

 Kreb’s Cycle

 Electron Transport
Chain
Glycolysis
 Input
• 1 Glucose (6C)
• 2 ATP
• 2 NAD

 Output
• 2 pyruvic acid (3C)
• net 2 ATP (4 ATP total)
• 2 NADH & 2H+
Fate of Pyruvic
Acid
 Anaerobic (see next slide)
• production of lactic
acid

 Aerobic
• formation of Acetyl
CoA
 Anaerobic
Respiration
 Input (from glycolysis)
• 2 pyruvic acid (C)
• 2 NADH & 2H+

 Output
• 2 lactic acid
• 2 NAD
• 2 ATP (net) from
glycolysis
Formation of Acetyl
CoA (aerobic)
 Input
• 2 pyruvic acids (3C)
• 2 NAD

 Output
• 2 acetyl CoA (2C)
• 2CO2
• 2 NADH & 2 H+
Kreb’s Cycle
 Input
• 2 acetyl Co A (2 C)
• 6 NAD
• 2 FAD
• 2 GDP

 Output
• 2 x (3 NADH & 3 H+)
• 2 x 1 FADH2
• 2 x 2 CO2
• 2 x 1 GTP (ATP)
Electron
Transport Chain
 Input
2 NADH & 2 H+ (Glycolysis)
2 NADH & 2 H+ (Formation
of Acetyl Co A)
6 NADH & 6 H+ (Kreb’s Cycle)
2 FADH2 (Kreb’s Cycle)
6 oxygen molecules

 Output
• 26-28 ATP
• 6 water molecules
Table 25.1 p. 951
 Each NADH produced in mitochondria
produces 2-3 ATP (average 2.5)
 Each FADH2 produces 1-2 ATP (average 1.5)
 NADH produced in the cytoplasm transfers
electrons (H) to FADH2 in mitochondria
(therefore producing only 1.5 ATP each)
except in kidney, heart and liver where
NADH is allowed to enter mitochondria
Electron Transport Chain
 Input
2 NADH & 2 H+ (Glycolysis) x 1.5 ATP = 3 ATP
2 NADH & 2 H+ (Formation of Acetyl Co A) x 2.5 ATP = 5 ATP
6 NADH & 6 H+ (Kreb’s Cycle) x 2.5 ATP = 15 ATP
2 FADH2 (Kreb’s Cycle) x 1.5 ATP = 3 ATP
6 oxygen

 Output
• 26-28 ATP
• 6 water molecules
 Summary of Cell Respiration
(aerobic)
 C6H12O6 + 6 O2 6 CO2 + 6 H2O + 30-32 ATP

 Input
• 1 glucose (6C)
• 6 oxygen molecules

 Output
• 30-32 ATP
• 6 Carbon dioxides
• 6 water molecules