MOLECULAR IMPRINTED

POLYMERS: drug delivery

system
Aleeza Ajmal
Daniel Dodoo
Eziz Naryyev
Muhammad Luthfi Fajri
Suanto Syahputra
José Luis del Río Rodríguez GROUP 3
INDEX OF THE PRESENTATION
1. Molecular imprinted polymers
2. Uses of molecular imprinted polymers
3. MIP as a drug delivery system
4. Doxorrubicin delivery system
5. Metronidazole delivery system
6. MIP in drug-targeting strategy
7. Challenges in the future
8. References
1. Molecular imprinted polymers
▪ Artificial receptor of
target molecules
▪ It functions as
biomimetic way of
natural antibody-
antigen systems
1. Molecular imprinting technique

DOI: 10.1016/j.mset.2019.10.012
2. Uses of MIPs

Electrochemical sensors Antibodies and biological

Biomolecules detection
and biosensors receptors
 MIP
as a drug delivery
system
3. MIP as a drug delivery system
Why to use MIPs?
-Affinity of the template to the
functional monomer
-High drug loading capacity of an
MIP material

-Higher stability and durability

against harsh conditions
4. Doxorrubicin (DOX) delivery system

DOI: 10.1016/j.apsusc.2016.08.107
4. Doxorrubicin (DOX) delivery system

S-S bond

H bond
 5. Metronidazole (MZ) delivery system

Supercritical fluids
DOI: 10.1016/j.ijpharm.2018.03.010
CO2
6. MIPs in drug targeting strategy
- Surface of membrane proteins
are key markers
- Mutation in the extracelular
domain of proteins

- Inhibit the interaction between

the target protein and the
exogenous ligand
DOI: 10.1039/c7cc05894b
7. Challenges for the future
- Controlling the balance between
pharmacokinetics and
pharmacodynamics
- Selective recognition
- Efficacy of drug loading
- Behaviour of the MIPs in the
surrounding environment
8. References
 Zaidi, S. A. (2020). Molecular imprinting: A useful approach for
drug delivery. Materials Science for Energy Technologies, 3,
72-77.
 Zhang, K., Guan, X., Qiu, Y., Wang, D., Zhang, X., & Zhang,
H. (2016). A pH/glutathione double responsive drug delivery
system using molecular imprint technique for drug
loading. Applied Surface Science, 389, 1208-1213.
 Marcelo, G., Ferreira, I. C., Viveiros, R., & Casimiro, T. (2018).
Development of itaconic acid-based molecular imprinted
polymers using supercritical fluid technology for pH-triggered
drug delivery. International journal of pharmaceutics, 542(1-2),
125-131.
 Peng, S., Wang, Y., Li, N., & Li, C. (2017). Enhanced cellular
uptake and tumor penetration of nanoparticles by imprinting
the “hidden” part of membrane receptors for targeted drug
delivery. Chemical Communications, 53(81), 11114-11117.
Thank you
for your
attention!
Any questions?