The essencials of global for congnitive function

Translational Neuroscience • 8 • 2017 • 87-96

 Atrial fibrillation, cognitive decline and dementia

A FA aumenta o risco de infartos

cerebrais subclínicos e pode ser
causa de hipoperfusão.

Essas condições levam ao declínio

cognitivo e aumento do risco de
demência.

Independentemente, cardiopatia
atrial esquerda aumenta o risco de
Figure 1: Potential Mechanisms Linking Atrial Fibrillation (AF) with Cognitive Decline and Dementia
FA e está associada ao risco de AVC
independente da FA.

European Cardiology Review, 2016;11(1):49–53

 Cognitive disorders and dementia in CKD: the
neglected kidney-brain Axis

J Am Soc Nephrol 24: ccc–ccc, 2013

 Carbohydrates and cognitive function

1363-1950 Copyright 2018 Wolters Kluwer Health,

 Associations between sleep,
cortisol regulation, and diet: risk of
alzheimer disease

Advances in Nutrition 7(4):679-689 · July 2016

 Iron metabolism of the skeletal muscle and neurodegeneration

Front. Neurosci. 13:165.2019.

 Role of the gut microbiota in nutrition and health

BMJ 2018;361:k2179
 Gut microbiota: a modulator of brain plasticity and cognitive function in ageing

Healthcare 2015, 3, 898-916;

 Inflammatory mechanisms in neurodegeneration

Journal of neurochemistry, 2019.

 Immune changes and neurotransmitters: possible interactions in depression?

Progress in Neuro-Psychopharmacology & Biological Psychiatry 48 (2014) 268–276

NeuroScience, Inc. December 2012 121210-Gen-z8008
 Nitric oxide and pain: “something old, something new”

Acta Anaesthesiol Scand 2009; 53: 1107-1120

Homocysteine and vascular dementia
 Food for thought: how nutrition impacts cognition and emotion

Science of Food (2017) 1:7

 Omega-3 fatty acids: potential role in the management of early alzheimer’s disease

Clinical Interventions in Aging 2010:5 45–61

 N-3 long-chain PUFA-containing phospholipids and neuroprotection

Omega Fatty Acids in Brain and Neurological Health (Second Edition) 2019, Pages 249-265
 Omega-3 fatty acids: potential role in the management of early alzheimer’s disease

Clinical Interventions in Aging 2010:5 45–61

 Omega-3 fatty acids: potential role in the management of early alzheimer’s disease

Clinical Interventions in Aging 2010:5 45–61

 Entendendo a atividade adaptogênica

Ann. N.Y. Acad. Sci. 1401 (2017) 49–64

 Entendendo a atividade adaptogênica

Ann. N.Y. Acad. Sci. 1401 (2017) 49–64

 Diferenças entre estimulantes e adaptógenos

Natural Pharmacy 2003;7(4):1,19–20.

Melatonin and aging: prospects for human treatment
Relação melatonina e cortisol
Relação melatonina e cortisol
 Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression

BIOL PSYCHIATRY 2009;65/;732-741

 Adaptógenos em transtornos mentais e comportamentais

Psychiatr Clin N Am 36 (2013) 49–64

Adaptógenos

Rodilha rosea – dosagem 200 a 600 mg.

Ashwagandha – dosagem 300 a 1000mg.

Panax ginseng/ ginseng siberiano.

Proporcionam uma melhor adaptação a

situações extremas pelas glândulas suprarrenais
(ou adrenais) são as glândulas responsáveis
pela resposta ao stress.

Resposta a curto prazo: 2 a 4 semanas.

Longo prazo aumenta níveis de cortisol.

 Adaptógenos – modulam o cortisol

Ginseng - Panax ginseng 400mg/dia

Manjericão santo - Ocimum

500mg/2xdia - 75mg/100ml de agua
tenuiflorium
3,0% de withanolídeos
Ashwagandha - Withania somnifera
300 - 1.000mg/ 3x ao dia

Astragalus - Astragalus membranaceus 500mg/dia

Avosoy - 35% fitoesteróis 300mg/dia

 Stress, adaptógenos e sua avaliação: uma visão geral

Ray et al., J Pharma Reports 2016, 1:2

 Magnolia (magnolia officinalis) and phellodendron (phellodendron amurense) - Relora®

Dosagem de 250 mg de duas a três vezes ao dia

Normaliza os níveis de cortisol

Previne o ganho de peso associado ao estresse
Melhora humor - vigor - Diminui a fadiga e depressão
Reduz a compulsão alimentar causada pelo estresse

Journal of the International Society of Sports Nutrition201310:37

 Avena sativa L. - Neuravena®
Composto bioativos, como avenantramidas, saponinas e flavonoides (vitexina e isovitexina).
Melhora da saúde mental e performance cognitiva - Estímulo da memória recente e tardia - Melhora do
desempenho cognitivo em situações de estresse - Melhora da atenção, concentração e agilidade.
Redução do cansaço - Coadjuvante no gerenciamento do peso associado à deficiência de dopamina.
Contribui para reduzir a compulsão por alimentos salgados e café.
Melhora a qualidade do sono - Diminui a irritabilidade - Pode ser indicado para celíacos
Uso associado: 200 a 800 mg ao dia
Uso isolado: 400 a 800 mg ao dia

BERRY, Narelle M. et al. Acute effects of an Avena sativa herb extract on responses to the stroop color–word
test. The Journal of Alternative and Complementary Medicine, v. 17, n. 7, p. 635-637, 2011.
 Phytochemicals and cognitive health: are flavonoids doing the trick?

Biomedicine & Pharmacotherapy Volume 109, January 2019, Pages 1488-1497

 Phytochemicals and cognitive health: are flavonoids doing the trick?

Biomedicine & Pharmacotherapy Volume 109, January 2019, Pages 1488-1497

 Phytochemicals and cognitive health:
are flavonoids doing the trick?

Biomedicine & Pharmacotherapy Volume 109, January 2019, Pages 1488-1497

 The essentials of a global index for cognitive function

Translational Neuroscience • 8 • 2017 • 87-96

 Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults

2000 mg/day: ∼ 400 mg curcumin

Nutrition and Healthy Aging 4 (2018) 323–333

 Effect of chlorogenic acid intake on cognitive function in the elderly: a pilot study

330mg CGAs dissolved in 100mL of water

Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2018, Article ID 8608497, 8 pages
 Effects of composite supplement containing astaxanthin and sesamin on cognitive functions in people with mild
cognitive impairment: a randomized, double-blind, placebo-controlled trial

6mg or 12mg of astaxanthin

Journal of Alzheimer’s Disease 62 (2018) 1767–1775
 Dietary blueberry improves cognition among older adults in a randomized,
double-blind, placebo-controlled trial

(24 g/day, equivalent to 1 cup of fresh blueberries)

Eur J Nutr DOI 10.1007/s00394-017-1400-8
 Effects of creatine supplementation on cognitive function of healthy individuals:
a systematic review of randomized controlled trials

Experimental Gerontology 108 (2018) 166–173

 Anti-neuroinflammatory potential of natural products in attenuation of alzheimer’s disease

Frontiers in Pharmacology | May 2018 | Volume 9 | Article 548

 Botanicals and phytochemicals active on cognitive decline: the clinical evidence

Pharmacological Research 130 (2018) 204–212

 Short – term impact of a combined nutraceutical on cognitive function, perceived stress and depression in
young elderly with cognitive impairment: a pilot, double-blind, randomized clinical trial

Cognitive testing was assessed by the age and education adjusted mini-mental state examination (MMSE).
Perceived Stress Questionnaire (PSQ) and Index and Self-Rating Depression Scale (SRDS).

Bacopa monnieri dry extract 320 mg, L-Teanina 100 mg, Crocus sativus 30 mg, some vitamins (Vitamin B6 9,5 mg, Biotine
450 mcg, Folic acid 400 mcg, Vitamin B12 33 mcg, Vitamin D 25 mcg) and Cupper 2 mg.
8 semanas de tratamento

J Prev Alz Dis 2017;4(1):12-15

 COGNIGRAPE® - Vitis Vinifera L.
Proantocianidinas e antocianina especifica a M3G- malvina-3-glucoside

Ação Antioxidante
Preserva e melhora a perfomance cognitiva
Favorece a Neuroplasticidade
Melhora a atenção, linguagem, humor e
memoria imediata.
Variação de 24,9% no índice de ansiedade.
Variação de 15,8% no índice de depressão.
Dosagem: 200 a 300 mg ao dia

Front. Pharmacol., 31 October 2017 | https://doi.org/10.3389/fphar.2017.00776

 Choline: exploring the growing science on Its benefits for moms and babies

Nutrients 2019, 11, 1823

 Choline: exploring the growing science on its benefits for moms and babies

Nutrients 2019, 11, 1823

 Choline: exploring the growing science on its benefits for moms and babies

Nutrients 2019, 11, 1823

 Meta-analysis of randomized controlled trial son cognitive effects of bacopa monnieri extract

Journal of Ethnopharmacology
 Neuroprotective actions of estradiol revisited

Trends in Endocrinology and Metabolism, December 2011, Vol. 22, No. 12

 Multiple sclerosis: neuroprotective alliance of estrogen–progesterone and gender

Frontiers in Neuroendocrinology 33 (2012) 1–16

 Fitoestrógenos

Isoflavonas (Glycine Max L.) 40mg à 80mg

Red Clover (Trifolium pratense) 500 mg à 1000mg
Hops (Humulus lupulus) 100mg à 300 mg
Kudzu (Pueraria lobata) 100mg à 750 mg
Licorice (Glycyrrhiza species) 200mg à 1000 mg
Rhubarb (Rheum species) 500 mg
Yam (Dioscorea species) 750mg 3x ao dia
Chasteberry (Vitex agnus-castus) 500mg à 1000 mg

Planta Med. 2013 May; 79(7):538-553

 Neurobiological and neuropsychiatric effects of dehydroepiandrosterone
(DHEA) and DHEA sulfate (DHEAS)

4 mg/day for 7, 14 or 21 days by gastric

intubation;
100 lg/ml DHEAS in drinking water (resulting
in dose of 300–500 lg/day)
and chow containing 0.5% DHEA (25 mg/day);
200–250 mg DHEA pellet implant; daily s.c.
injections 10, 20, 40 mg/kg (40 mg effective)

Frontiers in Neuroendocrinology 30 (2009) 65–91

 Nootropic drugs: methylphenidate, modafinil and piracetam e population use trends, occurrence in the
environment, ecotoxicity and removal methods e a review

Chemosphere 233 (2019) 771e785

 Nootropic drugs: methylphenidate, modafinil and piracetam e population use trends, occurrence in the
environment, ecotoxicity and removal methods e a review

Chemosphere 233 (2019) 771e785

 Effect of alpinia galangal EnXtra® on mental alertness and sustained attention with or
without caffeine: a randomized placebo-controlled study

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION 2017, VOL. 36, NO. 8, 631–639