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Sequence of Events
Sequence of Events
smoker, occupational
exposure, history of TB
Pulmonary
Epithelial injury
Endothelial
Activated
proinflammatory and
profibrotic factors,
Decrease Immune
System
disfunction
Sequence
of Events
macrophages, neutrophils Hypertension
& myofibroblasts. Infection of TB
(Lung TB relapse)
TGF-β & ECM
(extracellular
Matrix) Activation of macrophages
infected with bacilli
Type I and II
alveolar cell damage Release inflammatory
cytokines (TNF-a, IL-1, IL-6)
Colagenation and
hyalination Night
Accumulation Alteration of brush ↓ Appetite Fever
inflammatory mediators border activity and/or sweats
Pulmonary and necrotic tissue in lung structure
Fibrosis
Release of ↓ Intake
Decreased of chemoreceptor
elasticity Irritating trigger zone
airway
↓ Bodyweight
Nausea
Shorthness of ↑ Mucus
Chronic cough
Breath production