PRESENETATION

I.V
ADMIXTURES
By- Rajiv Kumar
B.Pharma Practice
II Year

Rayat and Bahra University

Mohali
 IV ADMIXTURES

DEFINITION:
It is combination of one or more sterile products added
to an IV fluid for administration.
or
Pharmaceutical mixture of two or more drugs into a
Large bag or bottle of I.V fluid.
It must be sterile and pyrogen free
Aseptic techniques are used to mixed the products.
TYPES OF IV ADMIXTURES

There are three types of IV admixtures:

1. Infusions
2. Intermittent
3. Pre-mixed IV admixtures
 INFUSIONS
 More effective and less toxic than when given
intermittently
 Continuous
 Basic fluid and electrolyte therapy.
 INTERMITTENT
 Periodic administration
 Increased efficacy
 Reduced toxicity

PRE-MIXED ADMIXTURE
 Manufactured LPVs with additives
 Availability in many sizes
EXAMPLES
 Lidocain
 Potassium
 nitroglycerine
 IV ADMINISTRATION EQUIP
I.V SYSTEM CONSISTS OF :
• Drip chamber
• Injection port
• Roller clamp
• Catheter needle Hypodermic needle
• Catheter [may be central or peripheral]
• IV set attached to container
• Dripping set [control rate of fusion by
clamp]
Container
• May be
• Plastic bags
• Vial spike system
• Large volume parentral
• Add-vantage
PREPARATION OF IV ADMIXTURES

• Products used in preparation must be sterile and not c

ontaminated.

• It includes development and maintenance of:

• Good aseptic technique in the personnel who

prepare and administer sterile products.
• Sterile compounding area complete with sterilized eq
uipment and supplies.
• Skills needed to properly use laminar airflow work be
nch or laminar air flow hood.
OPENING OF
AMPULE
DRAWING LIQUID FROM VIAL
ROUTES OF
ADMINISTRARTION
Parenteral route ‘’para’’ & ‘’enteron’’ means ou
tside
the intestine & are following.
 I/V
 I/M
 S/C
 Intrathecal
 Oral, sublingual,
 Inhalation route