Sucralose

Artificial
Sweetener

Hoang Phuong Anh – K64 Talented Chemistry

Tran Phuong Mai – K64 Talented Chemistry

Hanoi, December 20th, 2020

 Table of Contents
01 02 03
INTRODUCTION SUCRALOSE SWEET TASTE &
METABOLISM

04 05
ADVANTAGES &
DISAVANTAGES SUMMARY
Introduction

01
Sucrose
 Sugar consumed
82 gram/day

36 gram/day Double
AHA

24 gram/day

Artificial Sweeteners: reduce calorie, maintain sweetness

“Guideline: Sugar intake for adults and children”. Geneva: World Health Organization.2015.4.
Relative sweetness of some sweeteners

Compound Relative Sweetness

Glucose 0.75

Sucrose 1

Fructose 1.75

Aspartame 150

Saccharin 350

Sucralose 600
Sucralose

02
 History

Sucralose was Approved in Sucralose was

discovered by Australia, approved in the
scientists from Tate 1991 New Zealand, 1998-1999 European Union.
& Lyle. US.

Sucralose was
1976 1993-1998 FDA approved 2004
first approved
sucralose for use in
for use in
food and beverage.
Canada.

Susan S. Schiffman, Kristina I. Rother (2013). Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues.
J Toxicol Environ Health B Crit Rev. 2013 Sep; 16(7): 399–451.
 Properties
Off-white amorphous solid

A high solubility in water

Stable in heat
600 times as
sweet as sugar
Not metabolized
Wide range of pH
and temperature

Sanchari Chattopadhyay, Utpal Raychaudhuri, Runu Chakraborty (2011). Artificial sweeteners – a review. J Food Sci Technol. 2014; 51(4): 611–621.
 Synthesis
CH3COOH, CAT

PCl5, CCl3CN

CH3OH, KOH

Fei Wang, Haibing He, Xin Yang, Yongzhu Yu, Zhisong Fan (2011). Method of Sucralose synthesis yield
Sweet Taste &
Metabolism

03
 Sweet Taste

• Binding of a molecule to a
receptor protein lead to
releasing a signaling.

• Adjoining sensory neuron

receive that signaling and
send impulses to the brain.

• In the brain, these signals

derived cause the actual
sensation of sweetness.

https://i1.wp.com/sitn.hms.harvard.edu/wp-content/uploads/2013/05/taste-thumb.png?fit=320%2C404
Sweet Taste

T1r3 appears to be the

primary receptor for
sweet substances. T1r3
has a well-defined
"pocket" where smaller
molecules may enter
and perhaps bind.
Depending on a good fit
of molecular shape and
the presence of groups
that interact chemically
make stabilize binding.
Sweet Taste

Sucrose binds fairly well to

T1r3 and hence leads to a
sweet sensation in the brain.

Sucralose binds to T1r3 much

more strongly than does
sucrose, owing to the differing
structures of the two
molecules. Sucralose is ~ 600
times as sweet as the same
amount of sucrose.
 Metabolism
Sucralose metabolism in
human body
Most of the products
be eliminated 1
aren’t reacting with
unchanged in 4 2%
the feces anything in the body, do
% not participate in the
be absorbed
and eliminated digestion and metabolism
in the urine
glucuronidation
of food, so it does not
products of generate any calories.
phase II detoxi-
fication in the
liver 8 The acceptable daily intake
4 (ADI) for sucralose in US is
% 5mg/kg body weight/day.

A Roberts 1, A G Renwick, J Sims, D J Snodin. Sucralose metabolism and pharmacokinetics in man

Advantage &
Disadvantage

04
 Advantages

Sucralose is an artificial
sweetener that has no calories and
can help individuals lose weight.

You can add sucralose to recipes

and create a low calorie alternative
that still tastes great.
 Advantages
Products containing sucralose
provide a sweet taste and are often
low or lower in carbohydrates,
which is important for diabetes.

Sucralose does not raise blood sugar

levels or otherwise affect blood
glucose control.
 Advantages

European Food Safety Authority (EFSA)

claims that sucralose has no effect on
tooth decay.

Sucralose is commonly found in oral

health products, such as chewing gum.
 Disadvantages

Animal studies suggest that there

might be a link between sucralose and
a reduction in beneficial gut bacteria,
with concerns this could result in
health issues.

Potential toxicity from habitual

sucralose ingestion. Historical in vitro
genotoxicity tests found that sucralose
was weakly mutagenic in a mouse
lymphoma mutation assay.
 Disadvantages

Research in 2019 revealed that when

sucralose is heated to ≥248°F (120°C)
it may dechlorinate and decompose
into compounds that are harmful
enough to risk consumer health.

ºC
SUMMARY
Sucralose is an artificial sweetener, 600 times
sweeter than sucrose and does not provide any

05
calories.

Although sucralose is used globally in reduced-

calorie and diet foods and beverages, it has
raised concerns such as potential toxicity from
habitual sucralose ingestion,etc.

It is important to comply with the correct

dosage and consult a nutritionist when using
sucralose in the diet.
Thanks
For Your Attendtion.

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