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    1. Mycobacterium tuberculosis infection leads to inflammation and damage of the lung parenchyma, releasing cytokines like TNF-α. 2. This causes increased mucus production, cough, fever, and loss of appetite. 3. Secondary bacterial infections can occur, further exacerbating the inflammation and cytokine release, potentially leading to sepsis.

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    1. Mycobacterium tuberculosis infection leads to inflammation and damage of the lung parenchyma, releasing cytokines like TNF-α. 2. This causes increased mucus production, cough, fever, and loss of appetite. 3. Secondary bacterial infections can occur, further exacerbating the inflammation and cytokine release, potentially leading to sepsis.

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    3 views11 pages

    Presentation 1

    Uploaded by

    safaridika
    1. Mycobacterium tuberculosis infection leads to inflammation and damage of the lung parenchyma, releasing cytokines like TNF-α. 2. This causes increased mucus production, cough, fever, and loss of appetite. 3. Secondary bacterial infections can occur, further exacerbating the inflammation and cytokine release, potentially leading to sepsis.

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    of 11

    TB + EFUSI PLEURA

    Spesific Process ( lung TB )

    Destructive lung parenchym

    Rupture of caseosa focus

    Pe ↑ tuberculoprotein in the pleural space

    Hipersensitivity reaction ( Delayed Typed Hypersensitivity )

    Pe ↑ Permeability Capiler

    Pleural Effusion

    SOB
    SOE
    COPD

    High Pressure of Colonization


    Pulmonary of bacteria
    Vascular

    Acute
    CPC
    Exacerbation

    Ischemic
    Hepatitis

    Cell Injury

    Elevation of
    CKMB & Trop I
    Uncontroled DM
    Infection of M tb Sequence of Event
    DM
    Inflamation
    process Imunocomprom
    ized
    TB disease
    Specific Process
    Secondary Infention
    ↑ TNF α
    Multipication CAP SOB
    bacteria Non specific
    Anorexia Bacteria
    Parenchym damage
    Increased mucous
    production Release of Various
    ↑ CRP
    Lost of Appetite cytokines

    Decrease Cough IL 1, IL 6,
    immunity TNF α, IFN- γ

    Intake ↓
    Fever
    Lost of Hypoalbuminemia
    BW
    Lung Tumor
    Sequence of event
    Pleural
    ↓ Immunity infiltration

    Inflamation process
    ↑ permeability
    capiler
    Release various
    cytokine
    Pleural
    TNF α, IL1, IL3 IL Effusion
    7 TNF α, IL 1,
    IL 3, IL 6,
    Loss of IL 8
    appetite SOB

    Leucocytosis
    SOE Non Spesific
    Infection

    Inflamation
    process

    Increase Release various


    mucous of cytokines
    production

    IL-1, IL-6, IFN- γ ↑ TNF α

    SOB
    Anorexia

    Cough Fever
    Lost of Appetite

    Leucocytosis Intake ↓

    Lost of BW Hypoalbuminemia
    SOE Diabetes
    Mellitus

    Immunocompromise
    MTb disease

    Non spesific Infection of MTb


    infection
    Increase of
    TNFα Increase of
    Produce IL-1, Inflamation
    mucous
    IL-6 process
    production
    Appetite Increased of
    supression intathoracal
    Fibrosis Cough pressure
    Fever

    Loss of
    Alveoli rupture
    body Hyponatremia
    SOB weight
    Pneumothora
    x

    SOB
    Lung Tumor
    Sequence of event
    Pleural
    ↓ Immunity infiltration

    Inflamation process
    ↑ permeability
    capiler
    Release various
    cytokine
    Pleural
    TNF α, IL1, IL3 IL Effusion
    7 TNF α, IL 1,
    IL 3, IL 6,
    Loss of IL 8
    appetite SOB

    Leucocytosis
    SOE
    M tb Infection
    ATD
    INH, Rifamfisin, Pirazinamid

    TB Disease

    Multiplication of Spread
    bacteria extra pulmonary

    Faringitis TB Minor drug side effect


    Inflamation process

    Parenchymal damage

    Throat pain
    Release various of cytokines

    Nauseous

    ↑ TNF α
    Cough
    IL-1, IL-6, IFN- γ

    Anorexia

    Fever
    Lost of Appetite

    Leucocytosis
    Intake ↓

    Lost of BW Body weakness


    Sequence of event
    Lung Tumor

    Pleural
    ↓ Immunity infiltration

    Secondary i/banal infection of the lung


    parenchyma ↑ permeability
    capiler
    Release various
    cytokine
    Pleural
    TNF α, IL1, IL3 Effusion
    IFN δ
    IL 7

    Loss of Sub febrile


    appetite SOB

    ↓ intake anemia

    Loss of Hypoalbuminemia
    BW
    SOE Non Spesific
    Infection

    Inflamation Lung Tumor


    process

    Increase Release various


    mucous of cytokines
    production

    IL-1, IL-6, IFN- γ ↑ TNF α

    SOB
    Anorexia

    Cough Fever
    Lost of Appetite

    Leucocytosis Intake ↓

    Lost of BW Hypoalbuminemia
    SEQUENCE OF EVENT
    TB disease M.TB Infection Release of Various
    cytokines

    Inflammation Process of Other Bacterial


    lung parenchyma Infection IL 1, IL 6,
    TNF α,
    IFN- γ
    ↑ Mucous Release of cytokine
    production
    TNFα, Cellular influx to the Fever
    PGE2 alveolar, cytokines
    Cough release
    hypothalamus
    Increase permeability of Bacterimia
    Suprese alveolar capillary
    appetite Sepsis
    Consolidation
    Decrease
    intake Respiratory
    SOB failure
    Loss of body
    weight

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