Manufacturing of paracetamol

Mahnoor Andaleeb
CHEM51F20R040
Uses of Paracetamol
(acetaminophen)

To relieve
• Headach
• Cold and fever
• Tootache
• Muscle ache
Paracetamol of
different brands

 Tylenol
 Panadol
 Calpol
 Mapap
 Alvedon
 panamax
 P- Aminophenol (PAP) 80 to 95 %

Raw Acetic anhydride

materials Excipients ( binders, fillers, Lubricants and

disintegrants)

Solvents
Synthesis of paracetamol

There are two

methods for
synthesis of
paracetamol drug.

Conventional
Green method
method
Conventional method
 STEP 1
.
Step 2 (reduction)
3rd Step (Nucleophilic addition reaction)
Mechanism of 3rd step
Drawbacks of conventional method

% atom economy is 36 % High environmental impact Resource consumption

Green method
(Hoechst
Celanese
method)
IT IS DIRECT ACETYLATION
OF PHENOL WITH ACETIC
ANHYDRIDE AND HF AS
CATALYST.
Manufacturing process

Weighing Granulatio
and mixing n

Dry Wet
granulation granulation
Dry
granulation
Wet
granulation
 Quality controls

Coating
Manufacturing
process
Labelling

Storage and distribution

Recommended
dosage
Children (6-16 years)
 Paracetamol six plus suspension (250
mg/5 mL): 5 mL every 4 hours, up to 4
times a day
 Maximum daily dose: 500 mg (25 mL) in
24 hours
Adults and children 12 years and over

 Paracetamol tablets, syrup, and

suppositories: 500 mg every 4-6 hours,
up to 4 times a day
 Maximum daily dose: 4000 mg (8 x 500
mg tablets or equivalent amount of
syrup) in 24 hours This Photo by Unknown author is licensed under CC BY-SA.