HARBAL PLANT WITH ANTIPYCHOTIC

ACTIVITY
Bachelor of pharmacy
In faculty of science and technology

Presented by : SUJATA ARUN DHENGALE

Guided by : Dr . PARIMAL KATOLAKAR SIR

AMAR SEVA MANDAL'S

KAMLA NEHRU COLLEGE OF PHARMACY

BUTIBORY , NAGPUR –441108

 INTRODUCTION [1]

 Psychosis is one of the most complex and costly illness .

 The meaning of psycho is mind or soul and word -osis corresponds to an abnormal condition
in Greek .
 Psychosis is often describing as an involving a loss of contact with reality .

 It is characterized by three general types of symptoms :

 Positive symptoms : It is refers to loss of contact with reality and comprise of

hallucination ,delusions ,positive formal thought disorders .

 Negative symptoms : It is refers to a diminution in or absence of normal behaviour .

 Cognitive symptom : It is refers to manifest as deficits in attention, memory, learning,

concentration functions.
RISK FACTORS OF PSYCHOSIS :[2]

 A family history of psychosis or psychotic disorders .

 A neurodegenerative disorders [ such as Alzheimer and Parkison's]

 Chemical imbalance in the brain such as dopamine ,glutamate , acetylcholine, serotonin and
norepinephrine.

 Drug abuse or traumatic injury.

 LIST OF HERBAL DRUG WITH ANTIPSYCHOTIC ACTIVITY

Name Family Part Extract Mechanism of Picture

Isolated Action
Amblygonocarpus Mimosaceae Stem Aqueous It reduced [3]
Andongensis Bark locomotor
activity

Abelmoschus Malvaceae seed Decoction • It is [4]

esculentus CNS stimulant
and
antidepressant
• Dopamine
receptor is
highly
encourage
Arachis Fabaceae Leaves and Linalool It influence the [5]
hypogea stem N-hexadecanoic neurotransmitor
related to
circadian rhythms
in specific portion
of brain

Alliumcepa Liliaceae Bulb Paste It inhibited dopam [6]

ineargic
neurotransmission
and possibly
blocks
dopamine D2
receptor
Alafzelia Fabaceae Stem Bark Aqueous It reduce
Africana locomotor
activity and
stereotypy
behaviour

Bryophyllum Crassulaceae Leaves Methanol • It have

pinnatum sedative
effects and
depressant
action on CNS
• It alter
behaviour
pattern
Datura Solanaceae Seeds and Tropane • Muscarinic
Stramonium Leaves Alkaloids acetylcholineste-
rase receptor
antagonist
• It give sedative
action for
psychotic patient
and for treating
insomnia

Morinda Rubiaceae Fruits Methanol • It gives antidop- [7]

Citrifolia aminergic actions
• It induce
stereotypy
behaviour and
climbing time
Ocimum Lmiaceae Leaves Ethanol It induce locomotory
Sanctum activity and
dopamine level

Piper Piperaceae Fruits Essential Oil It inhibit dopamine

guineense neurotransmission
schum & thonn at D1/ D2 receptors
by the beta
sesquiphallandrene
chemotype present
in essential oils
 REFERENCES
1. Parle M, Sharma K. Schizophrenia: A review. Int Res J Pharm 2013;4:5

2. Parle M, Sharma K. Biomarker and causative factor of schizophrenia. Int Res J Pharm 2013;4:78-85

3. Nwinyi FC, Ajoku GA, Aniagu SO, Kubmarawa D, Enwerem N, Dzarma S, et al. Pharmacological justification for the
ethnomedicinal use of Amblygonocarpus andongensis stem bark in pain relief. Afr J Biotechnol 2006;5:1566

4. AGARWAL, A., DEEPIKA, B., CHANDERPRIYA, A., RATENDRA, K. & VEERMARAM, C. 2015. CNS stimulant and
antidepressant activity of seeds of abelmoschus esculentus in rats. Bulletin of Pharmaceutical Research 5(2): 47–
50.

5. ZU, X.Y., ZHANG, Z.Y., LIU, J.Q., HU, H.H., XING, G.Q., ZHANG, Y. & GUAN, D. 2010. Sedative effects of peanut
(Arachis hypogaea L.) leaf aqueous extracts on brain ATP, AMP, adenosine and glutamate/GABA of rats. Journal of
Biomedical Science and Engineering 3: 268–273.

6. . Kadian R, Parle M. Evaluation of anti-psychotic effect of Allium Cepa. World J Pharm Pharm Sci 2014;3:1146-5

7. Pandy V, Narasingam M, Mohamed Z. Antipsychotic-like activity of noni (Morinda citrifolia Linn.) in mice. BMC
Complement Altern Med 2012;12