IRON METABOLISM AND

IRON DEFICIENCY
ANAEMIA
PRESENTED BY-
GRASHI ALI (26)
HAFIZUR ROHMAN(27)
HEEYAI MEETEI(28)
IBRAHIM ALI(29)
ISAHAQUE ALI(30)
INTRODUCTION
IRON

 IT ’S A TRACE ELEMENT
 TOTAL BODY CONTENT 3-5 gm
 SOURCE –GREEN LEAFY VEGETABLES
- JAGGERY,PULSES,CEREALS
-DRY FRUITS,RAGI
 RDA(RECOMMENDED DIETARY ALLOWANCE)
ADULT MALE -10gm
ADULT FEMALE-20gm
PREGNANCY AND LACTATION-40gm
NOTE:
• MILK IS A POOR SOURCE OF IRON
•DURING PREGNANCY - Fe TRANSFER TO
FOETUS –THIS OCCUR MAINLY IN THIRD
TRIMESTER-THAT’S WHY WE SHOULD GIVE
GOOD ORAL SUPPLEMENT DURING THIRD
TRIMESTER
 ABSORPTION,TRANSPORT AND STORAGE
 IN FOOD :Fe 3 + (ferric form)-oxidised form
 ABSORPTION-Fe2+(FERROUS FORM)-reduced form
FACTOS WHICH DECREASE IRON ABSORPTION :
 PHYTATE,OXALATES,PHOSPHATES
 TANNETS(TEA)
FACTORS WHICH INCREASE IRON ABSORPTION
 VITAMIN C
 CYSTEINE Fe3+ Fe2+
 ACIDIC PH(HCL)
STORAGE FORM :TWO PROTEIN

FERRITIN HEMOSIDRIN
 READILY  AGGREGATE OF
MOBILISABLE SEVERAL FERRITIN
 IRON STORES IN  HAS MORE IRON
LIVER ,SPLEEN AND CONTENT
BONE MARROW  RELEASE IRON SLOWLY
 STORES IN SPLEEN AND
LIVER
BIOCHEMICAL FUNCTIONS OF IRON

 COMPONENTS OF Hb
 TRANSFER O2 TO TISSUE AND CO2 TO LUNG
 ETC (cyt and FeS protein)
 ANTIOXIDANT
 DETOXIFICATION(cyt P450)
DISORDER:Fe DEFICIENCY ANAEMIA
 MOST COMMON NUTRITIONAL PROBLEM IN INDIA
 MICROCYTIC (small size RBC )
 HYPOCHROMIC (reduced amount of Hb)

LAB FINDINGS(diagnosis)
 Reduced Hb level ,reduced Fe content
 Reduced ferritin level ,reduced MCV
 Reduced serum Fe
 Decreased Reticulocyte count
 Increased TIBC(total iron binding capacity)
CAUSES
 DECREASED INTAKE
LOW DIETARY Fe CONSUMPTION

 INCREASED LOSSES
HEMOLYSIS:intra vascular hemolysis
HAEMORRAGE:mensturation

 INCREASED UTILIZATION
TREATMENT
 DIET:green leafy vegetables,nuts,dates,meat….
 IRON THERAPY
ORAL THERAP Y
Ferrous sulphate 200mg/day
ferrous fumarate 200mg/day
ferrous gluconate:300mg/day
 Vitamin C(increases iron absorption)
 Vitamin E supplement
 BLOOD TRANSFUSION( if there is excessive blood
loss)
THANK YOU
Y
ARIGATO THAGATCHARI