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Attachment 1
Attachment 1
Attachment 1
Cerebrospinal Fluid is a
clear colourless body
fluid situated in the
Central Nervous System
(CNS).CSF flows in the
Ventricular system,
subarachnoid space and
central canal of the spinal
cord.
Cerebrospinal Fluid
About 500ml of CSF is
produced everyday by
specialized ependymal
cell located in the
Choroid Plexus.
Functions of CSF
>Cushioning of brain and
intracranial
neurovascular structures
Cerebrospinal Fluid
>Transport of
neuromodulators and
neurotransmitters
>Removal of waste
>Neural bouyancy
Cerebrospinal Fluid
• Cerebrospinal fluid is
produced by a
specialized tissue called
the choroid plexus.
Choroid plexuses are
located in the walls of
the lateral ventricles
and in the roofs of the
third and fourth
ventricles.
Cerebrospinal Fluid/Choroid
Plexus
• Choroid cells take up
various chemicals from
the underlying blood
vessel which they use to
actively secrete the CSF.
Thus, the CSF fluid is
not simply an
ultrafiltrate of blood but
differs from it in terms
of its electrolyte,and
protein content.
Clinical Correlation
Hydrocephalus
Impairment in CSF
circulation at any point
could result in
hydrocephalus.
This results in an increase
in CSF volume in the
Ventricular System.
Hydrocephalus
Also, there is a significant
abnormal enlargement of
the cerebral ventricle.
Classification of
Hydrocephalus
>Communicating or non-
communicating
hydrocephalus
Hydrocephalus
>Congenital
hydrocephalus
>Acquired hydrocephalus
>Communicating
hydrocephalus:
Occurs when CSF flow is
not blocked.This is
caused due to impaired
absorption by the
arachnoid granulations.
Hydrocephalus
>Non-communicating
hydrocephalus
There is obstruction to
the flow of CSF from the
ventricular system to the
subarachnoid space.
Hydrocephalus
Obstruction usually occur
at narrow passages such
as: foramen of Monroe,
cerebral
aqueduct,median and
lateral foramina of the
fourth ventricle.
Hydrocephalus
>Acquired
hydrocephalus:It is
caused by etiologies such
as:tumour, hemorrhage,
infection etc.
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