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BR1 - PSP - Physiology of Labor
BR1 - PSP - Physiology of Labor
PHYSIOLOGY OF
LABOR
Presenter: dr. Muthia Puspasari
Moderator: Dr. dr. Nuswil Bernolian, Sp.O.G, Subsp. K.Fm, MARS
3 Prostaglandins Role
7 Uterotonins in Parturition
Phase 3
AMNION CHORION
• Provides the fetal membranes’ tensile strength • Protective tissue layer and provides
resist membrane tearing and rupture immunological acceptance
• Highly resistant avascular tissue to • Enriched with enzymes that inactivate
penetration by leukocytes, microorganisms, uterotonins
and neoplastic cells • Inactivating enzymes such as prostaglandin
• Selective filter prevent fetal particulate dehydrogenase, oxytocinase, and
from reaching the maternal compartment. enkephalinase
SEX STEROID HORMONE ROLE
SEX STEROID HORMONE ROLE
ESTROGEN • At the end of pregnancy mediate uterine activation and cervical ripening
Estrogen:
NUCLEAR Progesterone:
Estrogen receptor α (ERα) and
RECEPTOR PR-A and PR-B
estrogen receptor β (ERβ)
PROSTAGLANDINS ROLE
PROSTAGLANDIS ROLE
Prostaglandins are lipid molecules with hormone-like actions play prominent role
myometrial contractility, relaxation, and inflammation.
The amnion is likely the major source for amnionic fluid prostaglandins, in
addition to the myometrium
Figure 2. Overview of the prostaglandin biosynthetic pathway. PG = prostaglandin; PGDH =
prostaglandin dehydrogenase; PGE2 = prostaglandin E2; PGF2α = prostaglandin F2α; PGH2 =
prostaglandin H2; PGHS = prostaglandin H synthase; PGI2 = prostaglandin I2; PLA2 = phospholipase
A2; PLC = phospholipase C.
PHASE 1: UTERINE QUIESCENCE
AND
CERVICAL SOFTENING
THE PHASES OF PARTURITION
Figure 3. Labor course divided on the
basis of expected evolution of the
dilatation and descent curves into three
functional divisions.
THE QUIESCENCE OF PHASE
1
MYOMETRIAL RELAXATION & CONTRACTION
Quiescence Contractility
Diminished intracellular crosstalk and reduced Enhanced interactions between the actin and
intracellular Ca2+ levels, myosin proteins,
Uterotonin degradation
Figure 5. Uterine myocyte relaxation and contraction. A. Uterine relaxation is maintained by factors that increase
myocyte cyclic adenosine monophosphate (cAMP) levels. B. Uterine contractions result from reversal of these
sequences.
• Suppression of prostaglandin production here persists
DECIDUA throughout most of pregnancy, and suppression
withdrawal is a prerequisite for parturition
• Matrix disorganization
Cervical Ripening • Inflammatory changes
Changes in Uterine
Ancillary Forces Cervical Changes
Shape
• Each contraction Contraction of the • Effacement and dilation
gradually elongates the abdominal muscles and occur in the ripened
ovoid uterine shape (5- forced respiratory efforts cervix fully dilate to
10 cm and narrows the with the glottis closed a diameter of 10 cm
horizontal diameter. pushing • cervical dilation is
• The lower segment and divided into latent and
cervix are flexible active phases
pulled upward and
around the lower pole of
the fetus
Figure 12. Schematic showing effacement and
dilation. A. Before labor, the primigravid cervix is
long and undilated in contrast to that of the
multipara, which has dilation of the internal and
external os. B. As effacement begins, the multiparous
cervix shows more dilation and funneling of the
internal os compared with the primigravid cervix. C.
As complete effacement is achieved in the
primigravid cervix, dilation is minimal. The reverse
is true in the multipara.
Figure 13. Hydrostatic action of membranes in effecting cervical effacement and dilation. With labor progression, note the
changing relations of the internal and external os in (A), (B), and (C). Although not shown in this diagram, with membrane
rupture, the presenting part, applied to the cervix and the forming lower uterine segment, acts similarly.
SECOND STAGE: FETAL DESCENT
• In normal labor a typical hyperbolic curve is formed when the station of the fetal
head is plotted
• During second-stage labor the speed of descent is maximal and is maintained until the
presenting part reaches the perineal floor
• The important component of the floor levator ani muscle and the fibromuscular
connective tissue that covers its upper and lower surfaces
• The most marked change: stretching levator ani muscle and thinning of the central
portion of the perineum (almost transparent membranous structure less than 1 cm thick)
• When the perineum is distended maximally, the anus becomes markedly dilated and
presents an opening (2 to 3 cm in diameter) and through which the anterior wall of the
rectum bulges.
THIRD STAGE: DELIVERY OF PLACENTA AND MEMBRANES
• This stage begins immediately after fetal delivery and involves separation and expulsion of the
placenta and membranes
• This sudden diminution in uterine size is inevitably accompanied by a decrease in the area of the
placental implantation site
• Cleavage of the placenta is aided greatly by the loose structure of the spongy decidua
• Membranes usually remain in situ until placental separation is nearly completed peeled of the
uterine wall, partly by further myometrium contraction and partly by traction that is exerted by the
separated placenta as it descends during expulsion.
• Completion of the third stage alternately compressing and elevating the fundus, while exerting
minimal traction on the umbilical cord
Figure 14. Diminution in size of the
placental site after birth of the newborn. A.
Spatial relations before birth. B. Placental
spatial relations after birth.
Figure 15. Postpartum, membranes are
thrown up into folds as the uterine cavity
decreases in size.
UTEROTONINS IN PARTURITION
PHASE 3
UTEROTONINS IN PARTURITION
PHASE 3
Oxytocin
• Strikingly rising in myometrial and decidual tissues near the end of gestation
• Synthesis directly in decidual and extraembryonic fetal tissues and in the placenta
• Maternal serum oxytocin levels are elevated: during phase 3 of parturition, early
puerperium, and breastfeeding
UTEROTONINS IN PARTURITION
PHASE 3
Prostaglandin fetal membranes &
placenta produce
prostaglandins
• Levels of prostaglandins increased during labor