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Lecture 1 - MBM 110
Lecture 1 - MBM 110
BIOCHEMISTRY
Lecture 1;
-Bioenergetics and Biological oxidation
KIUT
1st Semester, 2023/2024
02/14/2024 FKBIWOTT/BIO121/2023-2024 1
Bioenergetics
• Also known as biochemical thermodynamics
• It deals with the study of energy changes in living cell
(transfer and utilization).
• The reactions are broadly classified as exergonic
(energy releasing) and endergonic (energy
consuming).
• It is concerned with the initial and final states of
energy component of the reactants and not the
mechanism of chemical reactions.
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Free energy
• The energy actually available to do work (utilizable) is
known as free energy.
• Changes in the free energy (△G) are valuable in predicting
the feasibility of chemical reactions.
• The reactions can occur spontaneously if they are
accompanied by decrease in free energy.
• During a chemical reaction, heat may be released or
absorbed. Enthalpy (△H) is a measure of the change in
heat content of the reactants, compared to products.
• Entropy (△S) represents a change in the randomness or
disorder of reactants and products. Entropy attains a
maximum as the reaction approaches equilibrium.
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Metabolism
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Metabolism
• Broadly divided into two categories
1. Catabolism : The degradative processes concerned with
the breakdown of complex molecules to simpler ones,
with a concomitant release of energy.
2. Anabolism : The biosynthetic reactions involving the
formation of complex molecules from simple precursors.
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Catabolism
02/14/2024 FKBIWOTT/BIO121/2023-2024 6
Catabolism
02/14/2024 FKBIWOTT/BIO121/2023-2024 7
Stages for catabolism
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Anabolism
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