Hypersensitivity

Aquarina Hapsari
Choirunisa Nur Humairo
IKGA 2019
 How hypersensitivity appeared?

Proteksi
Overreaction Cell damage

Hipersensitif
Hypersensitivity type 1 / Immediate Hypersensitivity

Asthma
Local
Urticuria
Reaction

Systemic Anaphylaxis
Hypersensitivity
type 1 First exposure Ag
Sensitization Mast cell binding
Ig E
Stage
Subsequent
Effector exposure Ag
Damage host tissue
 Sensitization stage

Baso-
phil

Differentiation
Th 2

Dendritic
CD 4
memory
Ig E Y Y
Ag cell
MHC II
Th 2 Mast
Th 2
B cell
B cell
effector cell memory

IL 4
IL 5

Activate
Eosi-
nophil
 Effector stage

Late phase

Prostaglandine & Leukotrienes

Chemotractan
Leukocytes infiltration
Tissue damage
Bronchospasme
Mast
Degranulation
cell
Y Y
Y
Histamine Mast

Y
Eosi-

Y
cell
Y Y nophil
Early phase
Vasodilatation
Vessel permeablity
Y YY
Baso

Y
Makrofag

Y Y
phile
Bronchospasme Y
 Hypersensitivity II / Cytotoxic
Hypersensitive/ Antibody
Mediated Hypersensitive
Mediated Ig G & Ig M
Complement Activation
1. C3a, C4a,C5a  chemotractan terhadap
leukocyte
2. Membrane Attack Complex (MAC)
3. C3b  Opsonization / phagocytosis opsonization
ADCC (Antibody Dependent Cell-
Mediated Cytotoxic)  Natural Killer Cell
perforin & granzymes
Target Cell Dysfunction
 Type III Hypersensitivity

Arthus Reaction/ Local Systemic

• Injection • Raynaud
Tetanus vaksin -> Phenomenon
indurasi kulit Adanya cyanosis pada
• Inhale hidung, ujung tangan
Pigeon Breeding dan kaki akibat
Disease/ bird fancier’s cryoglobulin yang
lung (histoplasmosis menghambat kapiler
e.c.fungi) • Sistemic Lupus
• Ingested Eritematosus
Gluten -> Celiac Kompleks imun
Disease mengikat endotel ->
vasculitis
 Type III Hypersensitivity Mechanism

Kemotaktik
Neutrofil

C5a C3b
Aktivasi Komplemen C1 Granula
sitotoksik
C1 (ROS)
Soluble antigen c cc vccc vcvc c c
berupa c vc cv cv cv vc v
vc vc vc vvc v v

C3b
medikasi/venom v vv
v

Tissue Damage
 Type IV Hypersensitivity Delayed
Hypersensitivity

CD4 Helper T Cell CD8 Cytotoxic T Cell

T Cell

Coordinate Terjadi pada:

Terjadi pada: the Attack Do 1. Pancreas Islet Cell
1. Poison Ivy DM I
2. Nickel Allergy
the Attacking
2. Thyroid epithelial
3. Tuberculin Test cell Hashimoto
on Skin Thyroidosis

48-
72
Inflammation jam
and
Tissue Damage
 CD8 Cytotoxic T Cell Mediated Hypersensitivity

CD8 Cytotoxic T Cell

Perforin
c cc c
c c vc vcv cv vc v

v vc vc vc c
v v cv c
v vvc cv vvc cc
v c vc v c
vc vc c c
c c c vc cv cv vc c Granzyme

v v
vc vc vc vc v v
v vv v

Apoptosis
 CD4 Helper T Cell Mediated Hypersensitivity

Lysosomal Enzyme Naive CD4 Helper T Cell

Complement Component
Reactive oxygen species

Urushiol B7
CD28
Poison Ivy c cc ccc cc c c
c ccvcvvcvv cv cv v
v cvvcvv vvvIL-12
vv v v
Membocorkan Th 1 Cell
barrier endotel
c cc vccc c c c

c cc
vvvccvvcvc cc
vcvcvcc c

v vcvcvv cc
Proinflammatory Cytokines c vc cv vcv v v

v v
c

v v cv
vc vc vvcc vc c v

v
v v vc v v
v vc vc v c
v v cv c
v vvc cv vvc cc
v c cv c IL-2
vc vc c c
v
c c

v v
v v
IFN γ
c

TNF, IL-1, IL-6

Immune cells
datang Aktivasi Makrofag Proliferasi Th Cell
Th 1 Cell
 Naive Th Cell Maturation

IL-6
TGF β

c cc c
c c vc vcv cv vc v
c vc cv cv vc c IL 17
vc vc vc vc v v
v vv v

Th 1 Th 17 Untuk
mendatangkan
neutrofil
Kesimpulan