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    Researchers identified the tumor suppressor KEAP1 as an off-target of the modified protein AMG510 through global profiling. They found that AMG510 binds to KEAP1 and inhibits its function, leading to activation of antioxidant pathways in cells. Experiments showed AMG510 treatment stabilized KEAP1 and increased expression of its target genes.

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    Researchers identified the tumor suppressor KEAP1 as an off-target of the modified protein AMG510 through global profiling. They found that AMG510 binds to KEAP1 and inhibits its function, leading to activation of antioxidant pathways in cells. Experiments showed AMG510 treatment stabilized KEAP1 and increased expression of its target genes.

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    4 views9 pages

    10 1016-j Isci 2023 106080figure

    Uploaded by

    andreicontor572
    Researchers identified the tumor suppressor KEAP1 as an off-target of the modified protein AMG510 through global profiling. They found that AMG510 binds to KEAP1 and inhibits its function, leading to activation of antioxidant pathways in cells. Experiments showed AMG510 treatment stabilized KEAP1 and increased expression of its target genes.

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    © All Rights Reserved
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    of 9

    Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an

    off-target

    Yini Wang, Bowen Zhong, Caixia Xu, Dongdong Zhan, Songhao Zhao, Hongxing Wu, Mingwei Liu, Xiaoling Lan, Danni Cai, Qian Ding,
    Biao Zheng, Jiong Lan, Qiang Lv, Yi Wang, Jun Qin

    iScience
    Volume 26 Issue 2 (February 2023)
    DOI: 10.1016/j.isci.2023.106080

    Copyright © 2023 The Authors Terms and Conditions


    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)
    Copyright © 2023 The Authors Terms and Conditions
    Figure 1

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions
    Figure 2

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions
    Figure 3

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions
    Figure 4

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions
    Figure 5

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions
    Figure 6

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions
    Figure 7

    iScience 2023 26DOI: (10.1016/j.isci.2023.106080)


    Copyright © 2023 The Authors Terms and Conditions

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