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MAINTAINING THE INTERNAL ENVIRONMENT

A CONSTANT DESPITE OF THE


EXTERNAL/ INTERNAL FLUCTUATIONS/STIMULI​

HOMEOSTASIS
WHY IS HOMEOSTASIS
IMPORTANT?
Because as Endothermic animals we rely on the
optimized activity of the enzymes for various metabolic
processes.

Therefore it is really important to maintain


-An optimum temperature
-An optimum pH
-A balanced state of body fluids
-Osmoregulation , for the efficient enzymatic activity
NEGATIVE
FEEDBACK DETECTORS
- Eg. Receptors detect the change

Through
When there impulses
is a
CONTROLLERS
deviation
Eg. Hypothalamus; Coordinate information & triggers
from
correction of the system by
“Set Point”
(in tissue
fluids) Through nerve
impulses &
EFFECTORS hormones
Eg. Performs the changes as directed by the
controllers
Through secretion of
NEGATIV hormones,
E changes by organs
FEEDBA
CK BODY REACHES A CONSTANT
BALANCED STATE
Organs that carry out
homeostasis
SKIN - Thermal regulation, Regulation of water, salts and
urea
KIDNEYS – Regulation of water and salts, urea in the
body
LUNGS - Regulation of Carbon Dioxide and water
LIVER – Regulation of body glucose content
Control centres in homeostasis

Hypothalamus
-for water, body temperature, and pH in blood

 Pancreas
•-for glucose content in blood
Thermal correction
NORMAL
TEMPERATURE 370

Body temperature Body temperature


(hot receptors in skin (cold receptors in skin
detects) detects)

HYPOTHALAMUS HYPOTHALAMUS
-receives impulses -receives impulses
NEGATIVE
FEEDBACK

Skin looses heat Skin retains heat back


- Vasodilation - Vasoconstriction
- Hairs lowered Normal - Hairs erected
- Excess sweat temperature - No sweat produced
production - Shivering response
REGULATION OF WATER
NORMAL
CONCENTRATION
IN BLOOD
Blood Water
Blood Water
-Concentrated
-Diluted

HYPOTHALAMUS HYPOTHALAMUS
-generates impulses -generates impulses
Pituitary gland stops Pituitary gland
producing ADH produce a lot of ADH
NEGATIVE
FEEDBACK

Collecting ducts Collecting ducts more


impermeable permeable
Excess water Normal water Higher Reabsorption of
discharged by the conc. In blood water, urine conc
kidney, urine dil.
REGULATION OF glucose

NORMAL BLOOD
GLUCOSE

Blood Glucose
Blood Glucose

PANCREAS
PANCREAS
Detects increase via
Detects drop via
receptors
receptors
- release of insulin by
release of insulin by
Beta cells NEGATIVE
FEEDBACK Alpha cells

Excess blood glucose


Glycogen converts to
converts to glycogen in
Normal glucose glucose in the liver
the liver and muscle
conc. In blood
cells
What is Diabetes (Type I)
• When the beta cells of the pancreas cannot produce
sufficient insulin to increase the permeability of the
liver and muscle cells to take up glucose from the blood
plasma following a spike in the blood glucose level; blood
glucose conc. Would be persistently elevated causing
Diabetes Type (I)

Treatment : Administering a dose of Insulin artificially/ externally

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