ANGIOGENESIS in TUMOR

By
Dr. Rida Younas
 Blood supply to cancer cells
• Tumor requires recruitment of new blood vessels to
grow into large mass
• In absence of blood supply it can grow into a mass
of 10^6 cells (a sphere of 2mm in diameter).
• At this stage division of the outside of cells is
balanced by death of those in center due to
inadequate supply of nutrients.
• Most tumors induce the formation of new blood
vessels that invade the tumor and nourish it called
as angiogenesis.
 Steps in angiogenesis
• Degradation of basal lamina that surrounds
the nearby capillary
• Migration of endothelial cell lining the
capillary into the tumor
• Division of endothelial cells
• Formation of a new basement membrane
around the newly elongated capillary
 Con…
• Many tumors produce the growth factors that stimulates
the angiogenesis
• Other tumors induce the surrounding normal cells to
synthesize and secrete such factors
• Tumors secrete various growth factors i.e. basic
fibroblast growth factor, Transforming growth factor
alpha, vascular endothelial growth factor
• New blood vessels nourish the growing tumor allow to
increase in size and additional mutation to occur.
Adjacent blood vessels facilitate the process of
metastasis.