BS-480 Chemistry Analyzer

International IVD Clinical Application Dept.

Contents
Market position

 BS-480 is the upgrade version of BS-400 , share same platform software with BS-

800 & BS-2000, CL-2000i. Will bring customer added value with new features and
design.

 Constant 400 tests per hour for chemistries, up to 560 tests per hour with ISE.

 Customer: Low to medium volume tests lab, with 60~120 samples/day, or

600~1200 T/day.
Main features
Features
Throughput Constant 400T/H, up to 560T/H with ISE
Reagent/sample 80 reagent positions and 90 sample positions
position
Reagent volume R:10~350μl, step by 1 μl

Sample volume 1.5 ~45uL,0.1uL step

Reagent/sample 1 reagent probe and 1 sample probe
probe
Reaction cuvettes Reusable, 90 positions
Reaction volume 120~360μl
Optical system Halogen-tungsten lamp, grating system

Cooling system 2~10˚C, 24 hour non-stop cooling

Washing system 8-step washing system with preheated detergent

and water
Liquid system Pump

Absorption range 0~3.3Abs

Water consumption 20L/H
Sample Disk

 90 sample positions totally

 30 positions each cycle, 3 cycles

 60 positions with barcode scanning

 LED indicator: real-time monitoring of sample tray status

 Conductive material: enhanced liquid level detection sensitivity

Sample probe
Sample Container Specification Dead Volume

Sample Cup Φ14×25mm, 0.5ml 70μl

Φ14×25mm, 2ml 150μl
Φ12×37mm, 2ml 100μl
Primary tube or plastic tube Φ12×68.5 mm 8mm more over the
Φ12×99 mm unacceptable sample
Φ12.7×75 mm level height  Eppendorf tube need to load into primary
Φ12.7×100 mm
Φ13×75 mm
tube.
Φ13×95 mm  16mm primary tube (urine tube) not
Φ13×100 mm
supported.

Intelligent liquid level detection to minimize the

minimum dead volume

Enhanced probe movement smoothness and

liquid system to ensure the precision of 1.5 μl
sampling
Sample Probe Washing

 High pressure water for interior

washing
 Water bubble elimination before
washing
 Independent enhanced washing for
probe
 Water fall washing for exterior

 Carry-over <0.05% =500ppm

 Internal standard :266ppm
Reagent Disk

 80 positions, onboard chemistries: up to

78 (acid position is cancelled) New
carousel
cover
cover
 Internal barcode reader (optional) and
closed system (optional)

 24 hours non-stop cooling at 2~10°C

 New carousel cover with less

condensed water
Reagent probe

 Reagent volume:10 ~350 μl

 Reagent Bubble Detection

 Intelligent collision protection in vertical and

horizontal directions and intelligent auto-
recovery once collision happens

 Detection for insufficient and empty

 High pressure water washing for interior and

water fall washing for exterior

 Carry-over <0.05% =500ppm

 Internal standard :8.6ppm

Reaction System

 90 borosilicate glass (quarz) cuvettes

 Minimum reaction volume: 120μl

 Dray bath, maintenance free

Liquid System
 Combine the advantage of BS-800
series liquid system platform
 Largely decreased the dissolved air in
the deionized water and minimum sample
volume is as low as 1.5μl
 Larger water volume in interior probe,
carry-over decreased to 0.05%
 Precise control for washing liquid with
higher vacuum, enhanced washing
efficiency with overflow prevention
 With quartz cuvette, the detergent is
diluted 50 times, much less consumption of
detergent
Teflon tube, longer lifetime, never get
“yellow”
Easy to Use
 All liquid tanks are placed in the front of machine, easy to
replace, maintenance and trouble shooting

 Much easier to replace ISE reagent kit

 Easy to replace lamp and ISE module

 High concentration waste is drained by waste pump

 Available at over 2000m by external pump

Deionized
water ISE reagent

Detergent
Operation software
 Touch screen design

 Reagent dilution function, support

concentrated reagent

 Step by step maintenance guide

 Sample integrity check: auto serum index

 Auto re-run function, reflex test function

 Optimized result display, out of linearity

range result only show flag (< or > than
linearity range)
 Closed system
Classification Parameter Quantity
ALT, AST, GGT, ALP, ALB, TP, PA, TBA, CHE, BIL-T, BIL-D,
Hepatic Panel 13
5’-NT, AFU

Renal Panel CREA, UREA, UA, CO2, Cys-C, β2-MG, RBP, MALB 8
Cardiac Panel CK, CK-MB, a-HBDH, LDH,HS-CRP, HCY,MYO,D-Dimer 8
Inorganic & Anemia Mg, P, Ca, FER, Fe,UIBC, TRF, G6PD 8
Lipid Panel TC, TG, HDL-C, LDL-C, Apo-A1, Apo-B, Lp(a) 7
 A total solution: calibrators, quality control and
Immune Panel C3, C4, IgA, IgG, IgM,IgE 6
reagent are all provided by Mindray.
Diabetes Panel  High Glu, HbA1C,and
quality β-HB, FUN
cost-competitive 4
Rheumatism Panel Perfect match
RF, ASO, CRPthe instrument 3
Free of worry on the reagent application
Pancreatitis Panel AMY, LIP 2
 Quick response to performance issues
Lung Panel ADA, ACE 2

Total: 61
BS-480 evaluation in South Africa
 2015.5
 Lancet laboratory
 Method comparison with Cobas 6000
 Evaluation parameters: ALT,AST,GGT,ALP,ALB,TP,TB-
D,DB-D,CK,LDH,UREA,UA,Crea-J,Glu-
HK,HDLC,TC,TG,Ca,Mg,P,CO2
CRP, HbA1C
 Mindray reagent system Paramete Co- Y=intercept X=slope N
r efficient
Na 0.9499 -4.8973 1.0318 41

K 0.9968 0.3127 0.9658 43

Cl 0.9690 1.4395 0.9628 43

Urea 0.9987 -0.1219 0.9948 43

Crea 0.9969 2.8133 1.0396 43

CRP 0.9811 -6.4966 1.0076 40

ALP 0.9999 4.61 0.97 17

GGT 0.9997 -5.15 1.03 16

AST 0.9998 -1.29 1.01 19

Centre Hospitalier
Universitaire
de Montpellier, France

The most famous hospital

in the south France

16 © 2012 Mindray Confidential

Contents
Competition Analysis-International

Integra 400Plus Selectra ProXL

Cobas C311

RX Imola
Pictus700 BT3500
Cobas C311

Plastic cuvette
rack and replace
by rack

Ultrasonic mixer C pack reagent

Cobas C311 versus BS-480

Constant 400 T/H without

300 T/H without ISE
ISE
Separate cuvette and more
Plastic cuvette rack and need
economical
to replace by rack

Direct solid heating

Water bath, need to maintain
technology

Ultrasonic mixing Two separate mixers

Integra400Plus
Integra400Plus versus BS-480

Constant 400 T/H without

Up to 400 T/H
ISE
Disposable cuvettes, not Permanent glass cuvettes
convenient
Direct solid heating
Air bath, not stable
technology

Ultrasonic mixing Two separate mixers

RX Imola versus BS-480

400T/H without ISE 400 T/H without ISE

Precision pipetting: 2 μl Precision pipetting: 1.5μl

Cooling system: 8~15℃ Cooling system: 2~10℃

150μl minimal reaction 120μl minimal reaction

volume volume
OEM from FURUNO,
Cost-effective
expensive
Pictus 700 versus BS-480

Up to 600T/H, 780T/H with ISE 400 T/H without ISE

180μl minimal reaction volume,

120μl minimal reaction volume
50% higher

Air bath, not stable Direct solid heating system

Filter Grating
Selectra ProXL versus BS-480

320T/H without ISE, up to

400 T/H without ISE
450T/H with ISE

No independent mixer, high

Two independent mixers
carry over

No traceability, just traceable Traceable to international

to industry standards reference methods or materials

Filter Grating
BT3500 versus BS-480

360T/H+190ISE/H 400 T/H without ISE

180μl minimal reaction 120μl minimal reaction

volume, 50% higher volume

45 reusable cuvettes 90 reusable cuvettes

No independent mixer Two independent mixers

Built-in computer, difficult to
External computer
operate
Competition Analysis-Domestic

Chemray-420
LW C400

Urit-8060
CS-400
LW C400
Specification Details

Constant 360T/H Much slower

150μl minimal reaction volume 25% higher consumption
ISE module Couldn’t be provided
Preheating of reagent probe No
Clot detection No
Liquid level detection Low sensitivity, many bugs
CS400
Specification Details
Throughput Constant 400T/H

Heating system Water bath

Reagent position 90pcs

Sample position 115pcs

Traceability No
Urit-8060
Specification Details
Throughput Constant 400T/H
Reagent position 59pcs
Sample position 75pcs

Minimal reaction volume 180μl,50%higher consumption

Absorbance range 0~3Abs
A Total Solution for Clinical Chemistry

Title in
here

Original
Original Mindray Total quality
system pack
reagent Solution control

Title in
here
Original
calibrators with
traceability
Sales points

 Advanced optical • Low reaction volume

system
 More fully washing • Less dead volume
 Probe Carry-over
<0.05% • Easier maintenance

• Touch screen  Inherited BS-800

and BS-2000 series
software platform
and UI design
Thank You