How Zuranolone is used to treat Postpartum Depression

Malak Zuranolone benefits and side Clinical Trial and Efficacy of

UB number:163654
 Introduction
• PPD is the feeling of
stress, anxiety or
depression after birth.
 Symptoms
• Sleep Disturbances
• Fatigue
• Inability to bond with
the baby
• Loss of interest or
pleasure
Mechanism of GABA receptors:
effects : Zuranolone:
The drug's mechanism involves Across the completed studies in the
Benefits: enhancing GABAergic neurotransmission, Zuranolone clinical trial program, patients
● Cost Effective calming neural activity. GABA, an receiving Zuranolone consistently
● Orally taken experienced improvement in depressive
inhibitory neurotransmitter, mitigates
● Better performance symptoms by regulating excessive symptoms following a 2-week treatment
Side effects: neuronal firing, thereby ameliorating course. Treatment with Zuranolone was
● Weakness conditions associated with hyperactivity generally well tolerated with a consistent
● Dry mouth or overstimulation. safety and tolerability profile.
● Abdominal pain
Chemical Structure of Zuranolone

Relatively New Drug: Usage And Administration: References:

Zuranolone has recently
been approved by the FDA
in August 2023 and is
being sold under the brand
name Zurzuvae.
Conclusion:
• PPD is mental disorder in women
after birth.
• Results in anxiety, stress and
fatigue
• Zuranolone used in its treatment.
• Rajkowska G. O'Dwyer G. Teleki Z. Stockmeier C.A. Miguel-
• 50mg PO qPMx 14 days Hidalgo J.J. GABAergic neurons immunoreactive for calcium-
• binding proteins are reduced in the prefrontal cortex in major
Capsule PO route depression. Neuropsychopharmacology. 2007; 32: 471-482
Contraindications: • Yan C.G. Chen X. Li L. et al. Reduced default mode network
May cause embryo-fetal harm when
functional connectivity in patients with recurrent major
depressive disorder. Proc Natl Acad Sci U S A. 2019; 116: 9078-
administered to pregnant women. 908