MEIOSIS:

NON-DISJUNCTION
Wasna Al Saif
Table of contents

01 02 03
Introduction Nondisjunction in Nondisjunction in
meiosis I meiosis II
 Introduction
Nondisjunction is the failure of homologous chromosomes or sister
chromatids to separate properly during cell division. This results in extra
chromosomes on gametes
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2
Types of nondisjunction
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Types of nondisjunction
Meiosis I
Occurs during anaphase I, when
homologous pairs fail to separate
All four daughter cells will be affected
(two = n + 1 ; two = n – 1)
Meiosis II
Occurs during anaphase II, when sister
chromatids fail to separate
Two daughter cells will be affected
(two = n ; one = n + 1 ; one = n – 1)
 Diagram
This diagram shows how nondisjunction
occurs in different stages of meiosis.
 Effects of nondisjunction
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Nondisjunction can cause pregnancy loss or birth of
a child with extra chromosomes
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Down-syndrome
★ Down syndrome occurs when a child
is born with 3 chromosomes instead
of 2 in the 21st chromosome.
★ This is called Trisomy 21.
★ It is more likely that nondisjunction
occurred in the egg cell
★ Maternal age increases the chance of
down syndrome.
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