JURNAL READING

ALLERGY AND
IMMUNOLOGY DIVISION

Platelet concentrate and

type II IL-1 receptor are
risk factors for allergic
transfusion reactions in
children
WENJING HU , LI FENG , MENG LI ,
TING LI , YUDONG DAI AND XIAOWEI
WA N G

Criticized by
Muhammad mustaqiblat
Abstract
Purpose: Allergic transfusion reactions (ATRs) are immunological
reactions after transfusion. Interleukin-1 (IL-1) is a critical
regulator for human diseases. We performed this study to
investigate the association of type II IL-1 decoy receptor (IL1R2)
expression with ATRs in children.

Methods: Children received blood transfusions between January

and December 2019 were included. The age, sex, number and type
of blood transfusion, allergic history, and medical history were
collected and statistically analyzed. The blood samples were
collected from children with and without ATRs for detecting the
relative expression IL1R2 mRNA. Logistics regression analysis
was performed to identify the risk factors for ATRs in children. The
area under the receiver operating characteristic (ROC) curve (AUC)
was used to evaluate the predictive performance of risk factors
Results: Totally, 28,840 transfusions in 20,230 children, with 236
ATRs (0.82%) in 117 patients (0.58%) were included. ATRs were
common in children at the hematology-oncology department, in
children received higher number of blood transfusions, and older
children. Platelet concentrate induced a higher incidence of ATRs
(3.31%) than red cell concentrate (0.22%, p < 0.0001). After the
transfusion, IL1R2 mRNA level was higher in the blood samples in
children with ATRs than those without ATRs (p < 0.0001). Logistics
regression analysis indicated that platelet concentrate (95% CI 3.555,
293.782) and IL1R2 expression (95% CI 1.171 × 102 , 1.494 × 104 )
were independent risk factors for ATRs in children. IL1R2 expression
had high performance in predicting ATRs (AUC = 0.998, 100%
sensitivity and 98.85% specificity).

Conclusion: High IL1R2 expression level in children who received

blood transfusions may predict the morbidity of ATR.
introduction
 the most common
complications of blood
transfusions, especially
for the platelet transfusion

ATRs are
immunological this study to investigate the
reactions mediated by Allergic difference in IL1R2
the allergen- transfusion expression in pediatric
reactions patients with and without
dependent and -
(ATRs) ATRs after transfusio
independent pathways

(PAF IL-1 polypeptides, including IL-1α and

IL - 1
Monos ) IL-1β
it TNF
IL-6 and IL-8 with ATRs and
α
febrile nonhemolytic IL-1 and
transfusion reactions IL-1
(FNHTR) in pediatric patients receptor (IL1R2)
had been confirmed (IL1R1)
Materials and
methods
 Ethical approval was obtained from
the Ethics Committees of the
Children’s Hospital of Nanjing
Medical University, Nanjing, China.

FNHTR and
ATR
This study included children
(aged ≤18) who received
blood transfusion therapy
during January and
December 2019 at hospital.
classified and grouped according to
age (< 3 years, 3–6 years, 6–12
platelet suspended fresh- years and 12–18 years), sex, the
concen leukocyte- frozen number of transfusions received (1,
trate reduced red plasma 2–5 times, 6–10 times and > 11
blood cells (FFP), and times)
(SLRBC), cryoprecipi
tate
Blood collection and real-
time RT-PCR analysis
statistical analysis
Results
 No significant

No significant

significant

significant

significant
 01 02
Theory Theory
LITERATURE REVIEW

Neptune is the farthest planet in our Solar Venus has a beautiful name and is the
System. It’s the fourth-largest by diameter second planet from the Sun. It’s terribly
and the densest hot, even hotter than Mercury

03
Theory
Mercury is the closest planet to the Sun
and the smallest one in the Solar System
—it’s only a bit larger than our Moon
04
Theory
Despite being red, Mars is a cold place,
not hot. It’s full of iron oxide dust, which
gives the planet its reddish cast
AWESOME
WORDS
 26 27 28 29 30 31 1
WEEK
1

2 3 4 5 6 7 8
WEEK
2
SCHEDULE

9 10 11 12 13 14 15
WEEK
3

16 17 18 19 20 21 22
WEEK
4

23 24 25 26 27 28 29
WEEK
5
 JUPITER
Jupiter is the biggest planet in our Solar System and
also the fourth-brightest object in the sky
METHODOLOGY

VENUS SATURN
Venus has a beautiful name and is the Saturn is a gas giant, composed mostly
second planet from the Sun. It’s terribly of hydrogen and helium
hot
 TEST TEST TEST TEST TEST
1 2 3 4 5

Describe here your metrics 1

TEST

Describe here your metrics 2

Describe here your metrics 3

Describe here your metrics 4

 30,000 2,000
Sample size Cases that need further research
RESULTS ANALYSIS

If you want to modify this graph, click on it, follow the If you want to modify this graph, click on it, follow the
link, change the data and replace it link, change the data and replace it
 1,520
RESULTS ANALYSIS

Saturn is a gas giant,

composed mostly of
hydrogen and helium

5,000
Jupiter is the biggest planet in
our Solar System

3,250
Neptune is the farthest planet
from the Sun
 01
CONCLUSION
CONCLUSIONS
Jupiter is a gas giant and the
biggest planet in our Solar System.
It’s also the fourth-brightest object
in the sky, and its name comes
from the Roman god of the sky and
lightning
02
CONCLUSION
Mercury is the closest planet to the
Sun and the smallest one in the
Solar System—it’s only a bit larger
than our Moon. The planet’s name
has nothing to do with the liquid
metal
 03
CONCLUSION
CONCLUSIONS

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BIBLIOGRAPHY

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AUTHOR Year Title of the publication. Publisher

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