Huntington's

Disease
By: Moumin Ali
Table of contents

01 02 03 04
Introduction Causes Symptoms Diagnosis & cure
Overview and history What may cause the Symptoms/warnings Diagnosis of disorder
of the disorder disease to occur? signs of disease
Video of Huntington's
disease:
This video features Dr. Christopher using a
patient to illustrate the limits the patient faces
due to Huntington's disease.

The video is on your left …

Click the ‘Play’ button to start

 Overview and history of
Huntington's Disease:
Huntington's disease (HD) is a degenerative
neurological disorder characterized by uncontrolled
movements, cognitive decline, and signs of
schizophrenia. It was first described by George
Huntington, an American physician, in 1872. The
sickness was named after him. Huntington's disease is
caused by a mutated gene on chromosome 4 called HTT
(huntingtin gene).
 Causes of Huntington's disease:

Huntington's disease, a neurodegenerative condition, is

caused mostly by a mutation within the HTT gene,
which provides the blueprint for the huntingtin protein.
This genetic error follows a dominant autosomal
pattern, which means that if one parent contains the
mutant gene, each offspring faces a 50% chance of
inheriting the genetic strain. As a result, the
complicated genetic inheritance unfolds, creating an
intricate web of ancestral heritage. Lifestyle doesn't
matter because hereditary factors are what create the
sickness.
 Symptoms of
Huntington’s disease:
Early symptoms Late symptoms
● Mood swings ● Decline in cognitive ability

● Severe chorea
● Cognotive ability
● Difficulty swallowing and
speaking
● Involuntary movement
● Slowness of movement
● Impaired coordination
Over time, Huntington's disease gets worse
and causes serious issues with mood,
mobility, and thought processes. People
eventually depend on caregivers for
assistance with daily duties. For individuals
with HD and their families, early diagnosis
and treatment can improve their quality of
life.
Diagnosis of Huntington’s disease:
Huntington's disease is diagnosed by medical professionals
using neurological examinations, genetic testing, and
symptom evaluation. HD is inherited; it is not
communicable. There is currently no cure. The goals of
treatment are to reduce symptoms and enhance quality of
life. Drugs can assist with mobility and psychological
problems; therapy and support groups provide emotional
assistance. As HD worsens, people can require assistance
with everyday duties. Every year, thousands of people die
from it throughout the world as a result of severe
complications.
 Conclusion
In conclusion, schizophrenia, uncontrollable movements,
and cognitive impairment are some of the symptoms
associated with Huntington's disease, a neurological
condition. A disruptive protein known as mutant huntingtin
is produced when the HTT gene mutates, causing it to occur.
Mood fluctuations, memory problems, and mild involuntary
movements are some of early symptoms. See a doctor right
away if you observe any of these symptoms.