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Week 7 Oncology and Chemotherapy
Week 7 Oncology and Chemotherapy
• Neoplastic growth
• Causes in children versus adults
• Theories
• Genetic trigger
• Environmental irritation
• Cell mutation
• Oncogenic virus
NEOPLASIA
2020 NATIONAL HEALTH GOALS RELATED
TO CANCER AND CHILDREN #1
• Assessment
• Nursing diagnosis
• Outcome identification and planning
• Implementation
• Outcome evaluation
ASSESSING CHILDREN WITH CANCER
❖History
Weight loss, loss of appetite, easy bruising, swelling of any body part ,
headache, eye deviation
Family history of cancer
Swollen lymph nodes- Hodgkin
Nausea and Vomiting- brain tumor
Ecchymotic marks- leukemia
Pain and swelling in the large joints- osteosarcoma, ewing sarcoma
Eye deviations- brain tumor, retinoblastoma
Palpable mass in the abdomen- neuroblastoma, wilms tumor
❖Physical and laboratory examination
Biopsy
Surgical removal of tissue or cells for
laboratory evaluation and analysis
Benign or malignant neoplasm
Staging
• Stage 1- a tumor that has not extended to the
surrounding tissue and maybe completely
remove surgically
• Stage II- there is some local spread, but the
chance of surgical removal is good
• Stage III- cancer cells have spread to local
lymph nodes
• Stage IV- tumor spread
systematically(metastasis)
ASSESSING CHILDREN WITH CANCER
• Leukemia
• Distorted and
uncontrolled
proliferation of
WBC’s leukocytes
and is the most
frequently
occurring type of
cancer in children.
ASSESSING THE LEUKEMIAS
Neuroblastoma
Tumors that arise from the neuroectodermal cells of
the SNS, cells are highly undifferentiated and
invasive, and occur most frequently in the abdomen
• Arteriogram
• ultrasound, CT, or MRI scan of
chest, abdomen, pelvis;
• gallium bone scan; bone marrow
aspiration and biopsy
RHABDOMYO
SARCOMA
TUMOR OF
THE
STRIATED
MUSCLE
ASSESSING OTHER CHILDHOOD
NEOPLASMS
• Pain
• Imbalanced nutrition
• Risk for infection
• Disturbed body image
• Compromised family coping
CANCER TREATMENT
• Radiation therapy
• Utilizes radiation to destroy cancer cells and reduce the size of
tumors by causing damage to DNA
• Immediate side effects
• Fatigue, anorexia, nausea and vomiting
• Long-term side effects
• Long term complication or malignant
transformation
• Effects on bone
• Asymmetric growth of bones, easy fracturing, scoliosis,
kyphosis and hypoplasia(not reaching full growth
potential)
• Effects on hormones
• Radiation in the head and neck can result to long-term
thyroid, hypothalamic, and pituitary gland dysfunction,
resulting in growth hormone deficiency,
hyperprolactinemia, central adrenal insufficiency, or
gonadotropin deficiency
• Effects on the nervous system
• Demyelination and necrosis of white matter of the brain,
which results in symptoms of lethargy, sleepiness, and
possibly seizures and effects on gray matter, which result
in learning disabilities and cognitive challenges.
• Effects on organs of the chest, abdomen
• Extensive radiation to the lungs can result in chronic
pneumonitis and pulmonary fibrosis, resulting in
obstructive or restrictive chronic lung disease.
CANCER TREATMENT
• Radiation therapy
• Before treatment
• Radiation therapy as usually
marked on the child’s skin in
indelible ink or tattoo
• Do not apply lotion or cream
• During treatment
• Lie still
• No sensation from radiation
• Infants or young children are sedated
or given general anesthesia
• After treatment
• Reassessment, CBC,
• Evaluation for NV, poor oral intake and
hydration
CANCER TREATMENT
• Chemotherapy
• Types
• Alkylating agents-prevents cell division
• Antimetabolites- prevent replication
• Plant alkaloids- prevent DNA replication
• Antitumor antibiotics- disrupt protein synthesis
CANCER
TREATMENT
• Chemotherapy
• Types
• Nitrosoureas- DNA damage
• Corticosteroids- anti-swelling
• Immunotherapy- boost immune system
CANCER TREATMENT
• Chemotherapy
• Protocols
• Side effects and toxic
reactions
• Alopecia
• Cushingoid
appearance
CANCER
TREATMENT
• Stem cell
transplantation
• Pain relief