Health Science Institute Of

RCAF

Major : Pharmacy

Subject : Biology molecule

Topic :​mRNA Vaccine ( principle)

Professor : DARY CHHAVARATH

2022-2023
Group 5 : 12 Members
1 THY NISA 5 NGY SIVHOURNG 9 VEN JUMLEAKSMY

2 DOK DYBOLA 6 VIREAK CHANTHU 10 KIM SOMNANG

3 NAI LYHENG 7 PHORN RATHANA 11 SOPHAT SREYMEY

4 LY KIMLEANG 8 KHEM SOKHENG 12 LOEURM SOVANREAKSMEY

mRNA vaccine
Principle
 CONTENTS

01 02
What is mRNA vaccine? How do mRNA made?

03 04
How do mRNA vaccine work? Are mRNA vaccine
safe?

05 Warning & side effect

1. What is mRNA vaccine?

. Messenger RNA (mRNA)

-responsible for transferring genetic
information from DNA to protein.
-A template for protein translation.

. mRNA vaccine
- A novel vaccine technology which
delivers the mRNA that encoding the
antigen protein of pathogen to the cell
express the antigen protein, and then
stimulate the immune response of the body.
The origin of the mRNA vaccine is from
cancer research. But it was inconvenient
and unsuccessfully, during the spread of
COVID-19 at this period, the researcher
created an idea, which takes the spike
protein of the human body.
- Spike protein of the corona virus get into
human body.
 2.How do mRNA vaccine made?
. 6 STEPS OF PRODUCE VACCINE

1. Research

2. Test on animal

3. Test on human

4. Inspection and allow to production

5. Production process

6. Quality management
 3. How do mRNA vaccine work?
1 Spike protein 4 COVID-19 virus spike
covid-19 virus protein created

2 mARN with instructions

5 spike proteins are
for making the spike
recognized by the immune
protein is developed in a
system which produces
lab (mRNA vaccine)
specific antibodies against
COVID-19 virus
3 mRNA enters the
cell(human cell) 6 if you’re infected with
the COVID-19 virus,
antibodies bind to virus &
stop it from replicating
 4.Are mRNA vaccine safe ?
All vaccines, including mRNA vaccines, undergo rigorous quality control and quality assurance
protocols to ensure their safety and efficacy. Quality testing is integral to the development and
manufacturing processes. Data from these quality tests are submitted to the FDA for review before a
vaccine is made available to the public. After a vaccine is approved, both the Centers for Disease
Control and Prevention and the FDA continue monitoring its safety. Due to the public health
emergency that was declared because of the COVID-19 pandemic, the COVID-19 vaccines were
first authorized for emergency use. Additional data was reviewed before any mRNA vaccines were
approved by the FDA.
 5. Warning & Side effect
1. Warning

-Tell the vaccination provider about all of your medical conditions, including if you:

. Have any allergies

.have a fever

. Are pregnant or plan become pregnant

. Are breastfeeding

.have received another COVID-19 vaccine

 5.Warning & side effect
2 Wide effects that have been reported with the Pfizer-BIONTECH Covid-19 Vaccine

-injection site pain

-tiredness

-headache and chills

-muscle pain or joint pain

-fever

-nausea and feeling unwell

-injection site swelling

-injection site redness

 Reference
-https://qualitymatters.usp.org/what-is-mrna-and-how-does-it-work?gclid=Cj0KCQjw2v-
gBhC1ARIsAOQdKY1UbKA9sFSs4iK4I9YZYSr2M29ju7LFu-UqHdccqApK_XIb8d7dvuEaAi8vEALw_wcB

-https://images.app.goo.gl/1oMN8YcruJqbEmQC6

-https://classroom.google.com/c/NTE4MjIwNDUwNTQz?cjc=3s7ls3u
Thank you